Yazar "AAA-2998-2021" için listeleme
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Benzamide and Benzamidine Compounds as New Inhibitors of Urokinase-type Plasminogen Activators
Kus, Canan; Ozer, Ezgi; Korkmaz, Yesim; Yurtcu, Erkan; Dagalp, Rukiye (2018)Background & Method: In this ongoing research, it is aimed to investigate the synthesis, structure identification and effects on urokinase-type plasminogen activators (uPA) and its receptor levels of 4-(3H-imidazo[4,5-b] ... -
Does Theobromine Increase the Apoptotic Effect of STI571?
Kasap, Yesim Korkmaz; Ozdemir, Zeynep; Asparuk, Cagan; Ak, Oguzhan; Aysun, Dide; Akgor, Doga; Elmastas, Fulya; Akkus, Dogukan; Yurtcu, Erkan (2016)Objective: STI571, a selective tyrosine kinase inhibitor is used in CML chemotherapy. It has limited effects in some cases due to drug resistance and intoxication as other chemotherapeutic agents. Thus, many cancer patients ... -
Effect of Melatonin on Cytokine Levels in A Hyperthermia-Induced Febrile Seizure Model
Aydin, Leyla; Yurtcu, Erkan; Korkmaz, Yesim; Sezer, Taner; Ogus, Ersin (2017)Higher serum cytokine levels have been reported in children admitted with febrile seizures and in some experimental models. However, other studies have shown that cytokine levels are influenced by melatonin. In this study, ... -
Effect of mometasone furoate nasal spray on the DNA of nasal mucosal cells
Aydin, Erdinc; Akkas, Hakan; Turkoglu Babakurban, Seda; Yurtcu, Erkan; Yilmaz Ozbek, Ozlem (2018)Background/aim: Allergic rhinitis (AR) is a respiratory disease caused by inflammation of the nasal mucosa. Intranasal corticosteroids (ICs) are an effective treatment for AR; however, their use has been associated with ... -
Effects of Alendronate and Pamidronate on Apoptosis and Cell Proliferation in Cultured Primary Human Gingival Fibroblasts
Soydan, S. S.; Araz, K.; Senel, F. V.; Yurtcu, E.; Helvacioglu, F.; Dagdeviren, A.; Tekindal, M. A.; Sahin, F. (2015)Data arising from the recent literature directed the researchers to study on the degree and extent of bisphosphonate toxicity on oral mucosa in further detail. The aim of this study is to determine the half maximal inhibitory ... -
The Effects of Ozone Application on Genotoxic Damage and Wound Healing in Bisphosphonate-Applied Human Gingival Fibroblast Cells
Akdeniz, Sidika Sinem; Beyler, E.; Korkmaz, Y.; Yurtcu, E.; Ates, U.; Araz, K.; Sahin, F. I.; Torun, O. Y. (2018)Medication-related osteonecrosis of the jaws (MRONJ) is an extremely therapy-resistant disease involving the jaws especially following bisphosphonate treatment. Bisphosphonates accumulate in bone in concentrations sufficient ... -
Effects of Silymarin and Silymarin-Doxorubicin Applications on Telomerase Activity of Human Hepatocellular Carcinoma Cell Line HepG2
Yurtcu, Erkan; Iseri, Ozlem Darcansoy; Sahin, Feride Iffet (2015)Purpose: Hepatocellular carcinoma (HCC) is resistant to conventional chemotherapeutics such as doxorubicin. Milk thistle extract, or its active constituent silymarin has been used by cancer patients as an alternative and ... -
In Vitro Effects on Biofilm Viability and Antibacterial and Antiadherent Activities of Silymarin
Evren, Ebru; Yurtcu, Erkan (2015)Limited treatment options in infectious diseases caused by resistant microorganisms created the need to search new approaches. Several herbal extracts are studied for their enormous therapeutic potential. Silymarin extract, ... -
Semi-Automatic Scoring Tool for Comet Assay
Kiziltan, E.; Yurtcu, E. (2015)Comet assay or single-cell gel electrophoresis is a widely used method for DNA damage assessment. The results of the method can be scored under microscopic examination either with the naked eye or by automated systems. In ... -
Silymarin: Implications for Antibacterial and Antiadherent Activity
Evren, Ebru; Yurtcu, Erkan (2014)