DSpace at BASKENT UNIVERSITYDSpace dijital arşiv sistemi toplar, depolar, dizinler, korur ve dijital araştırma materyallerini dağıtmaya aracılık eder.http://acikerisim.baskent.edu.tr:802024-03-19T08:49:48Z2024-03-19T08:49:48ZComputational Prediction of MicroRNA Function and ActivityOgul, Hasanhttp://hdl.handle.net/11727/118602024-03-18T12:51:48Z2014-01-01T00:00:00ZComputational Prediction of MicroRNA Function and Activity
Ogul, Hasan
Inferring microRNA (miRNA) functions and activities has been extremely important to understand their system-level roles and the mechanisms behind the cellular behaviors of their target genes. This chapter first details methodologies necessary for prediction of function and activity. It then introduces the computational methods available for investigation of sequence and experimental data and for analysis of the information flow mediated through miRNAs.
2014-01-01T00:00:00ZThe Effect of Lichtenstein Tension-Free Mesh Hernia Repair on Couple's Sexual LifeHoscan, M. B.Karabulut, Z.Dogan, P.Tunckiran, A.http://hdl.handle.net/11727/118592024-03-18T12:51:54Z2014-01-01T00:00:00ZThe Effect of Lichtenstein Tension-Free Mesh Hernia Repair on Couple's Sexual Life
Hoscan, M. B.; Karabulut, Z.; Dogan, P.; Tunckiran, A.
2014-01-01T00:00:00ZMultidrug Resistance 1 (MDR1) 3435C/T Genotyping in Childhood Drug-Resistant EpilepsySaygi, SemraAlehan, FusunAtac, Fatma BelginErol, IlknurVerdi, HasibeErdem, Remzihttp://hdl.handle.net/11727/118582024-03-18T12:45:07Z2014-01-01T00:00:00ZMultidrug Resistance 1 (MDR1) 3435C/T Genotyping in Childhood Drug-Resistant Epilepsy
Saygi, Semra; Alehan, Fusun; Atac, Fatma Belgin; Erol, Ilknur; Verdi, Hasibe; Erdem, Remzi
Introduction: A mutation at nucleotide position 3435 in exon 26 of the multidrug resistance 1 (MDR1) gene is the most frequently studied polymorphism in relation to multidrug resistance. However, there are conflicting data as to whether the CC or TT genotype of the 3435C>T polymorphism is associated with drug resistance. Methods and results: We investigated the association between this polymorphism in drug-resistant childhood epilepsy by comparison with drug-responsive patients. In total, 59 patients with drug-resistant epilepsy, defined as having four or more seizures within a 12-month period while using three or more AEDs, 60 children with drug-responsive epilepsy who had remained seizure-free for 12 months on their current AED regimen and 76 healthy children were involved in this study. Genotype frequencies in drug-resistant patients were as follows: 32.2% CC, 44.1% CT, 23.7% TT; in the drug-responsive group: 20.0% CC, 50.0% CT, 30.0% TT; in the control group: 24.3% CC, 50.0% CT, 25.7% TT. Comparison of drug-resistant and drug-responsive patients revealed no significant difference in genotype frequency. The findings of the epilepsy patients were not significantly different from those of the healthy control subjects. Conclusions: Our study does not support any significant association between the MDR1 polymorphism and drug-resistant childhood epilepsy. (C) 2013 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
2014-01-01T00:00:00ZCardiovascular Surgeon's Perspective of the Iatrogenic Vascular Injuries in Gynecologic SurgeryAkay, Hakki TankutKorun, OktaySezgin, AtillaAslamaci, Saithttp://hdl.handle.net/11727/118572024-03-18T12:45:29Z2014-01-01T00:00:00ZCardiovascular Surgeon's Perspective of the Iatrogenic Vascular Injuries in Gynecologic Surgery
Akay, Hakki Tankut; Korun, Oktay; Sezgin, Atilla; Aslamaci, Sait
Background: This study aims to define basic parameters and to propose certain attitudes towards the management of such patients.
Methods: Data of the 18 gynecologic surgery patients (mean age 54.4 +/- 3.2 years; range 45 to 63 years) who were intraoperatively consulted to vascular surgery for vascular trauma between January 2003 and December 2012 were retrospectively analyzed. All patients had undergone a previous surgical procedure in the same surgical site.
Results: The vascular structures injured were the iliac arteries in eight patients, iliac veins in eight patients and inferior vena cava in two patients. The mean length of intensive care unit and hospital stays were 2.7 +/- 1.2 and 7.1 +/- 1.6 days, respectively. One patient died postoperatively.
Conclusion: We believe that favorable results for this potentially lethal complication can be achieved with individual management strategies tailored in accordance with certain principles.
2014-01-01T00:00:00Z