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dc.contributor.authorOzgun, Gonca
dc.contributor.authorEsendaglı, Guldal
dc.contributor.authorAkarca, F. Goknur
dc.contributor.authorBalci, Serdar
dc.contributor.authorArgon, Asuman
dc.contributor.authorSengiz Erhan, Selma
dc.contributor.authorTurhan, Nesrin
dc.contributor.authorInce Zengin, Neslihan
dc.contributor.authorHallac Keser, Sevinc
dc.contributor.authorCelik, Betul
dc.contributor.authorBulut, Tangul
dc.contributor.authorAbdullazade, Samir
dc.contributor.authorErden, Esra
dc.contributor.authorSavas, Berna
dc.contributor.authorBostan, Temmuz
dc.contributor.authorSagol, Ozgul
dc.contributor.authorAysal Agalar, Anil
dc.contributor.authorKepil, Nuray
dc.contributor.authorKarslioglu, Yildirim
dc.contributor.authorGunal, Armagan
dc.contributor.authorMarkoc, Fatma
dc.contributor.authorSaka, Burcu
dc.contributor.authorOzdamar, Sukru Oguz
dc.contributor.authorBahadir, Burak
dc.contributor.authorKaymaz, Esin
dc.contributor.authorIsik, Emre
dc.contributor.authorAyhan, Semin
dc.contributor.authorTuncel, Deniz
dc.contributor.authorOzguven Yilmaz, Banu
dc.contributor.authorCelik, Sevinc
dc.contributor.authorKarabacak, Tuba
dc.contributor.authorErbarut Seven, Ipek
dc.contributor.authorAtaizi Celikel, Cigdem
dc.contributor.authorGucin, Zuhal
dc.contributor.authorEkinci, Ozgur
dc.contributor.authorAkyol, Gulen
dc.date.accessioned2019-05-08T12:46:46Z
dc.date.available2019-05-08T12:46:46Z
dc.date.issued2018
dc.identifier.issn1018-5615
dc.identifier.urihttp://www.turkjpath.org/pdf/pdf_TPD_1840.pdf
dc.identifier.urihttp://hdl.handle.net/11727/3247
dc.description.abstractObjective: As there is continuing disagreement among the observers on the differential diagnosis between the epithelial changes/lesions and neoplasms of the gallbladder, this multicentre study was planned in order to assess the rate of the epithelial gallbladder lesions in Turkey and to propose microscopy and macroscopy protocols. Material and Method: With the participation of 22 institutions around Turkey that were included in the Hepato-Pancreato-Biliary Study Group, 89,324 cholecystectomy specimens sampled from 2003 to 2016 were retrospectively evaluated. The numbers of adenocarcinomas, dysplasias, intracholecystic neoplasms/adenomas, intestinal metaplasias and reactive atypia were identified with the review of pathology reports and the regional and countrywide incidence rates were presented in percentages. Results: Epithelial changes/lesions were reported in 6% of cholecystectomy materials. Of these epithelial lesions, 7% were reported as adenocarcinoma, 0.9% as high-grade dysplasia, 4% as low-grade dysplasia, 7.8% as reactive/regenerative atypia, 1.7% as neoplastic polyp, and 15.6% as intestinal metaplasia. The remaining lesions (63%) primarily included non-neoplastic polypoids/hyperplastic lesions and antral/pyloric metaplasia. There were also differences between pathology laboratories. Conclusion: The major causes of the difference in reporting these epithelial changes/lesions and neoplasms include the differences related to the institute's oncological surgery frequency, sampling protocols, geographical dissimilarities, and differences in the diagnoses/interpretations of the pathologists. It seems that the diagnosis may change if new sections are taken from the specimen when any epithelial abnormality is seen during microscopic examination of the cholecystectomy materials.en_US
dc.language.isoengen_US
dc.relation.isversionof10.5146/tjpath.2017.01404en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGallbladderen_US
dc.subjectCholecystectomyen_US
dc.subjectDysplasiaen_US
dc.subjectNeoplasiaen_US
dc.subjectSamplingen_US
dc.titleA Retrospective Evaluation of the Epithelial Changes/Lesions and Neoplasms of the Gallbladder in Turkey and a Review of the Existing Sampling Methods: A Multicentre Studyen_US
dc.typereviewen_US
dc.relation.journalTURKISH JOURNAL OF PATHOLOGYen_US
dc.identifier.volume34en_US
dc.identifier.issue1en_US
dc.identifier.startpage41en_US
dc.identifier.endpage48en_US
dc.identifier.wos000433250700004


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