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dc.contributor.authorAliskan, Hikmet Eda
dc.contributor.authorSari, Ayse Nur
dc.contributor.authorSuzuk, Serap
dc.contributor.authorKaratuna, Onur
dc.contributor.authorOgunc, Dilara
dc.contributor.authorKarakoc, Ayse Esra
dc.contributor.authorCizmeci, Zeynep
dc.contributor.authorComert, Fsun
dc.contributor.authorBakici, Mustafa Zahir
dc.contributor.authorAkpolat, Nezahat
dc.contributor.authorCilli, Fatma Feriha
dc.contributor.authorZer, Yasemin
dc.contributor.authorKaratas, Aysel
dc.contributor.authorKarapinar, Bahar Akgun
dc.contributor.authorBayramoglu, Gulcin
dc.contributor.authorOzdamar, Melda
dc.contributor.authorKalem, Fatma
dc.contributor.authorDelialioglu, Nuran
dc.contributor.authorAktas, Elif
dc.contributor.authorYilmaz, Nisel
dc.contributor.authorGurcan, Saban
dc.contributor.authorGulay, Zeynep
dc.date.accessioned2019-06-10T22:00:16Z
dc.date.available2019-06-10T22:00:16Z
dc.date.issued2017
dc.identifier.issn0374-9096
dc.identifier.urihttp://www.mikrobiyolbul.org/managete/fu_folder/2017-03/2017-51-3-299-303.pdf
dc.identifier.urihttp://hdl.handle.net/11727/3444
dc.description.abstractColistin is a polymyxin antibiotic which is considered as one of the last line agents against infections due to multidrug resistant or carbapenem resistant gram-negative pathogens. Colistin resistance is associated with chromosomal alterations which can usually cause mutations in genes coding specific two component regulator systems. The first plasmid-mediated colistin resistance gene, mcr-1 was described in Escherichia coli and Klebsiella pneumoniae isolates in December 2015 and followed by another plasmid-mediated colistin resistance gene mcr-2 in 2016. The rapid and interspecies dissemination of plasmid-mediated resistance mechanisms through horizontal gene transfer, have made these genes considerably threatening. After the first reports, although mcr-1/mcr-2 producing Enterobacteriaceae isolates have been reported from many countries, there have been no reports from Turkey. Thus, the aim of this study was to investigate the presence of mcr-1/mcr-2 in clinical Enterobacteriaceae isolates from different parts of our country. A total of 329 Enterobacteriaceae isolates from 22 laboratories were collected which were isolated between March, 2015 and February, 2016. mcr-1/mcr-2 were investigated by polymerase chain reaction during February-March, 2016. Two hundred and seventeen of Klebsiella pneumoniae (66%), 75 of Salmonella spp. (22.8%), 31 of Esherichia coli (9.4%), 3 of Enterobacter cloacae (0.9%), 2 of Klebsiella oxytoca (0.6%) and 1 of Enterobacter aerogenes (0.3%) isolates were included to the study. Agarose gel electrophoresis results of PCR studies have shown expected band sizes for positive control isolates as 309 bp for mcr-1 and 567 bp for mcr-2. However, the presence of mcr-1/mcr-2 genes was not detected among the tested study isolates of Enterobacteriaceae. Although mcr-1/mcr-2 were not detected in our study isolates, it is highly important to understand the mechanism of resistance dissemination and determine the resistant isolates by considering that colistin is a last-line antibiotic against infections of multidrug or carbapenem resistant gram-negative bacteria. Thus, it is suggested that these mechanisms should be followed-up in both clinical and non-clinical (e.g. isolates from food animals, raw meats and environment) isolates of special populations.en_US
dc.language.isoturen_US
dc.relation.isversionof10.5578/mb.57515en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColistinen_US
dc.subjectMcr-1en_US
dc.subjectMcr-2en_US
dc.subjectEnterobacteriaceaeen_US
dc.titleResults of a Multicenter Study Investigating Plasmid Mediated Colistin Resistance Genes (mcr-1 and mcr-2) in Clinical Enterobacteriaceae Isolates from Turkeyen_US
dc.typearticleen_US
dc.relation.journalMIKROBIYOLOJI BULTENIen_US
dc.identifier.volume51en_US
dc.identifier.issue3en_US
dc.identifier.startpage299en_US
dc.identifier.endpage303en_US
dc.identifier.wos000408311400011en_US
dc.identifier.scopus2-s2.0-85031327136en_US
dc.contributor.pubmedID28929967en_US
dc.contributor.orcID0000-0001-9060-3195en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergien_US
dc.contributor.researcherIDAAE-2282-2021en_US


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