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dc.contributor.authorSeckin, D.
dc.contributor.authorOh, C.C.
dc.contributor.authorHofbauer, G.F.L.
dc.contributor.authorSerra, A.L.
dc.contributor.authorHarwood, C.A.
dc.contributor.authorMitchell, L.
dc.contributor.authorProby, C.M.
dc.contributor.authorOlasz, E.B.
dc.contributor.authorMosel, D.D.
dc.contributor.authorPiaserico, S.
dc.contributor.authorFortina, A.B.
dc.contributor.authorGeusau, A.
dc.contributor.authorJahn-Bassler, K.
dc.contributor.authorGerritsen, M. J. P.
dc.contributor.authorGulec, A.T.
dc.contributor.authorCetkovska, P.
dc.contributor.authorRicar, J.
dc.contributor.authorImko-Walczuk, B.
dc.contributor.authorDebska-Slizien, A.
dc.contributor.authorBavinck, J. N. Bouwes
dc.date.accessioned2019-06-13T12:01:54Z
dc.date.available2019-06-13T12:01:54Z
dc.date.issued2017
dc.identifier.issn0007-0963
dc.identifier.urihttps://discovery.dundee.ac.uk/ws/files/11548197/Oh_et_al_2016_British_Journal_of_Dermatology.pdf
dc.identifier.urihttp://hdl.handle.net/11727/3499
dc.description.abstractBackgroundOrgan transplant recipients (OTRs) have a highly increased risk of cutaneous squamous cell carcinomas (SCCs). Sensation of pain in cutaneous tumours is a powerful patient-reported warning signal for invasive SCCs in OTRs. ObjectivesTo investigate the impact of painful vs. painless skin lesions and SCC vs. other skin lesions on the overall mortality risk in OTRs. MethodsWe followed 410 OTRs from 10 different centres across Europe and North America between 2008 and 2015. These patients had been enrolled in an earlier study to define clinically meaningful patient-reported warning signals predicting the presence of SCC, and had been included if they had a lesion requiring histological diagnosis. Cumulative incidences of overall mortality were calculated using Kaplan-Meier survival analysis, and risk factors were analysed with Cox proportional hazard analysis. ResultsThere was an increased overall mortality risk in OTRs who reported painful vs. painless skin lesions, with a hazard ratio (HR) of 16 [95% confidence interval (CI) 097-27], adjusted for age, sex and other relevant factors. There was also an increased overall mortality risk in OTRs diagnosed with SCC compared with other skin lesions, with an adjusted HR of 17 (95% CI 10-28). Mortality due to internal malignancies and systemic infections appeared to prevail in OTRs with SCC. ConclusionsWe suggest that OTRs have an increased overall mortality risk if they develop painful skin lesions or are diagnosed with cutaneous SCC.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1111/bjd.15269en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCANCERen_US
dc.subjectMALIGNANCYen_US
dc.subjectKIDNEYen_US
dc.titlePainful skin lesions and squamous cell carcinoma predict overall mortality risk in organ transplant recipients: a cohort studyen_US
dc.typearticleen_US
dc.relation.journalBRITISH JOURNAL OF DERMATOLOGYen_US
dc.identifier.volume176en_US
dc.identifier.issue5en_US
dc.identifier.startpage1179en_US
dc.identifier.endpage1186en_US
dc.identifier.wos000401338700059


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