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dc.contributor.authorKarakisi, Sedat Ozan
dc.contributor.authorKunt, Ayse Gul
dc.contributor.authorBozok, Sahin
dc.contributor.authorCankaya, Idil
dc.contributor.authorKocakulak, Mustafa
dc.contributor.authorMusabak, Ugur
dc.contributor.authorSargon, Mustafa Fevzi
dc.contributor.authorErgene, Saban
dc.contributor.authorIlhan, Gokhan
dc.contributor.authorKaramustafa, Hakan
dc.contributor.authorTufekci, Nebiye
dc.contributor.authorSener, Erol
dc.date.accessioned2019-06-21T08:57:21Z
dc.date.available2019-06-21T08:57:21Z
dc.date.issued2016
dc.identifier.issn1995-1892
dc.identifier.urihttp://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5340897&blobtype=pdf
dc.identifier.urihttp://hdl.handle.net/11727/3665
dc.description.abstractAim: To investigate and compare uncoated and phosphoryl-choline-coated oxygenators in terms of induction of humoral immune response during coronary artery bypass surgery. Methods: A total of 20 consecutive patients who underwent coronary artery bypass surgery were randomly distributed into two groups according to the type of oxygenator used during surgery. Group 1 consisted of 10 patients who were operated on using phosphorylcholine-coated oxygenators. Group 2 contained 10 patients who underwent surgery using uncoated oxygenators. Blood and oxygenator fibre samples were obtained and compared in terms of immunoglobulins (IgG, IgM), complements (C3c, C4), serum total protein and albumin levels using electron microscopy and flow cytometry. Results: In group 1, levels of IgM, IgG, total protein and serum albumin were significantly increased at the end of cardiopulmonary bypass (CPB) compared to those at the beginning of CPB. In group 2, C3c and C4 levels at the beginning of CPB were found to be significantly higher than at the end. Electron microscopic examination of oxygenator fibres demonstrated that phosphorylcholine-coated fibres were less likely to be adsorbed by serum proteins and complements than the uncoated fibres. Conclusion: Our results indicate that phosphorylcholine-coated oxygenators seemed to induce humoral immune response to a lesser extent than uncoated oxygenators during coronary artery bypass procedures.en_US
dc.language.isoengen_US
dc.relation.isversionof10.5830/CVJA-2016-003en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCardiopulmonary bypassen_US
dc.subjectOxygenatoren_US
dc.subjectPhosphorylcholineen_US
dc.subjectHumoral inflammationen_US
dc.titleHumoral immune response and coated or uncoated oxygenators during cardiopulmonary bypass surgeryen_US
dc.typearticleen_US
dc.relation.journalCARDIOVASCULAR JOURNAL OF AFRICAen_US
dc.identifier.volume27en_US
dc.identifier.issue4en_US
dc.identifier.startpage242en_US
dc.identifier.endpage245en_US
dc.identifier.wos000384800700018


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