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dc.contributor.authorShin, Su Ryon
dc.contributor.authorZihlmann, Claudio
dc.contributor.authorAkbari, Mohsen
dc.contributor.authorAssawes, Pribpandao
dc.contributor.authorCheung, Louis
dc.contributor.authorZhang, Kaizhen
dc.contributor.authorManoharan, Vijayan
dc.contributor.authorZhang, Yu Shrike
dc.contributor.authorYuksekkaya, Mehmet
dc.contributor.authorWan, Kai-tak
dc.contributor.authorNikkhah, Mehdi
dc.contributor.authorDokmeci, Mehmet R.
dc.contributor.authorTang, Xiaowu (Shirley)
dc.contributor.authorKhademhosseini, Ali
dc.date.accessioned2019-06-22T07:37:41Z
dc.date.available2019-06-22T07:37:41Z
dc.date.issued2016
dc.identifier.issn1613-6810
dc.identifier.urihttp://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5201005&blobtype=pdf
dc.identifier.urihttp://hdl.handle.net/11727/3680
dc.description.abstractBiomaterials currently used in cardiac tissue engineering have certain limitations, such as lack of electrical conductivity and appropriate mechanical properties, which are two parameters playing a key role in regulating cardiac cell behavior. Here, the myocardial tissue constructs are engineered based on reduced graphene oxide (rGO)-incorporated gelatin methacryloyl (GelMA) hybrid hydrogels. The incorporation of rGO into the GelMA matrix significantly enhances the electrical conductivity and mechanical properties of the material. Moreover, cells cultured on composite rGO-GelMA scaffolds exhibit better biological activities such as cell viability, proliferation, and maturation compared to ones cultured on GelMA hydrogels. Cardiomyocytes show stronger contractility and faster spontaneous beating rate on rGO-GelMA hydrogel sheets compared to those on pristine GelMA hydrogels, as well as GO-GelMA hydrogel sheets with similar mechanical property and particle concentration. Our strategy of integrating rGO within a biocompatible hydrogel is expected to be broadly applicable for future biomaterial designs to improve tissue engineering outcomes. The engineered cardiac tissue constructs using rGO incorporated hybrid hydrogels can potentially provide high-fidelity tissue models for drug studies and the investigations of cardiac tissue development and/or disease processes in vitro.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1002/smll.201600178en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGELATIN METHACRYLATE HYDROGELSen_US
dc.subjectMYOCARDIAL TISSUEen_US
dc.subjectCARBON NANOTUBESen_US
dc.subjectSTEM-CELLSen_US
dc.subjectDIFFERENTIATIONen_US
dc.subjectFABRICATIONen_US
dc.subjectCONSTRUCTSen_US
dc.subjectNANOSHEETSen_US
dc.subjectREDUCTIONen_US
dc.subjectPROSPECTSen_US
dc.titleReduced Graphene Oxide-GelMA Hybrid Hydrogels as Scaffolds for Cardiac Tissue Engineeringen_US
dc.typearticleen_US
dc.relation.journalSMALLen_US
dc.identifier.volume12en_US
dc.identifier.issue27en_US
dc.identifier.startpage3677en_US
dc.identifier.endpage3689en_US
dc.identifier.wos000383374800006


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