Show simple item record

dc.contributor.authorBeysel, S.
dc.contributor.authorKizilgul, M.
dc.contributor.authorOzbek, M.
dc.contributor.authorCaliskan, M.
dc.contributor.authorKan, S.
dc.contributor.authorApaydin, M.
dc.contributor.authorOzcelik, O.
dc.contributor.authorCakal, E.
dc.date.accessioned2019-06-30T20:20:03Z
dc.date.available2019-06-30T20:20:03Z
dc.date.issued2017
dc.identifier.issn11769092
dc.identifier.urihttp://go.galegroup.com/ps/retrieve.do?tabID=T002&resultListType=RESULT_LIST&searchResultsType=SingleTab&searchType=AdvancedSearchForm&currentPosition=1&docId=GALE%7CA531217464&docType=Report&sort=RELEVANCE&contentSegment=ZONE-MOD1&prodId=AONE&contentSet=GALE%7CA531217464&searchId=R3&userGroupName=baskent&inPS=true
dc.identifier.urihttp://hdl.handle.net/11727/3762
dc.description.abstractBackground: Cardiovascular disease (CVD) is reported to be higher in elderly diabetics. Serum heart-type fatty acid binding protein (H-FABP) is a serum marker of myocardial ischemia. We aimed to investigate the association between serum H-FABP level and conventional cardiovascular risk factors, inflammatory markers and subclinical atherosclerosis in elderly diabetics without overt CVD. Patients and methods: A total of 50 elderly diabetic patients without overt CVD and 30 age-, sex- and body mass index (BMI)-matched healthy controls were enrolled. Anthropometric and biochemical parameters, serum H-FABP, high-sensitivity C-reactive protein (hs-CRP), fibrinogen and carotid intima-media thickness (CIMT) were measured. Logistic regression analyses (adjustments for age, sex, hypertension, smoking, diabetes, BMI, blood pressure, lipid, blood glucose, hemoglobin A1c, hs-CRP and fibrinogen) were performed to evaluate the association between H-FABP and cardiovascular risk factors and atherosclerosis indices. Results: Serum fibrinogen (421.50±85.52 mg/dL vs 319.17±30.77 mg/dL, p=0.023), CIMT (0.70±0.12 mm vs 0.59±0.06 mm, p<0.001) and hs-CRP (5.72±4.50 mg/dL vs 1.60±0.72 mg/dL, p<0.001) were significantly higher in diabetic patients than controls. The mean serum H-FABP level did not differ between groups (1571.79±604.60 ng/mL vs 1500.25±463.35 ng/mL, p=0.905). H-FABP was positively correlated with fibrinogen (r2=0.473, p<0.001), hs-CRP (r2=0.323, p=0.003) and CIMT (r2=0.467, p<0.001). After full adjustments, the serum H-FABP level was independently associated with an increase in the fibrinogen level (odds ratio [OR] =4.21, 95% confidence level [CI] =1.49-11.90). Conclusion: Serum H-FABP was similar in the elderly diabetic patients without known CVD when compared with the nondiabetic control group. H-FABP does not possess a high diagnostic value as a cardiovascular marker when used alone; however, it may add supplementary information in patients with a high fibrinogen level. © 2017 Beysel et al.en_US
dc.language.isoengen_US
dc.relation.isversionof10.2147/CIA.S137247en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCardiovascular risken_US
dc.subjectElderly diabeticsen_US
dc.subjectH-FABPen_US
dc.titleHeart-type fatty acid binding protein levels in elderly diabetics without known cardiovascular diseaseen_US
dc.typearticleen_US
dc.relation.journalClinical Interventions in Agingen_US
dc.identifier.volume12en_US
dc.identifier.startpage2063en_US
dc.identifier.endpage2068en_US
dc.identifier.scopus2017-1


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record