| dc.contributor.author | Rohrbach, Daniel J. | |
| dc.contributor.author | Salem, Hakeem | |
| dc.contributor.author | Aksahin, Mehmet | |
| dc.contributor.author | Sunar, Ulas | |
| dc.date.accessioned | 2019-08-02T12:01:55Z | |
| dc.date.available | 2019-08-02T12:01:55Z | |
| dc.date.issued | 2016 | |
| dc.identifier.issn | 2304-6732 | |
| dc.identifier.uri | https://www.mdpi.com/2304-6732/3/3/48 | |
| dc.identifier.uri | http://hdl.handle.net/11727/3794 | |
| dc.description.abstract | One of the main mechanisms of action for photodynamic therapy (PDT) is the destruction of tumor vasculature. We observed the PDT-induced vasculature destruction in a mouse model of skin cancer using two techniques: Photoacoustic microscopy (PAM) and diffuse correlation spectroscopy (DCS). PAM showed high-resolution images of the abnormal microvasculature near the establishing tumor area at pre-PDT, as well as the subsequent destruction of those vessels post-PDT. DCS indicated a significant blood flow decrease after PDT, confirming the vascular destruction. Noninvasive assessment of vascular changes may be indicative of therapy response. | en_US |
| dc.language.iso | eng | en_US |
| dc.relation.isversionof | 10.3390/photonics3030048 | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | skin cancer | en_US |
| dc.subject | microvasculature | en_US |
| dc.subject | photoacoustic microscopy | en_US |
| dc.subject | blood flow | en_US |
| dc.subject | photodynamic therapy | en_US |
| dc.title | Photodynamic Therapy-Induced Microvascular Changes in a Nonmelanoma Skin Cancer Model Assessed by Photoacoustic Microscopy and Diffuse Correlation Spectroscopy | en_US |
| dc.type | article | en_US |
| dc.relation.journal | PHOTONICS | en_US |
| dc.identifier.volume | 3 | en_US |
| dc.identifier.issue | 3 | en_US |
| dc.identifier.wos | 000381860400008 | en_US |
| dc.identifier.scopus | 2-s2.0-85013224002 | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | en_US |
