Show simple item record

dc.contributor.authorMendi, Aysegul
dc.contributor.authorKose, Sevil
dc.contributor.authorUckan, Duygu
dc.contributor.authorAkca, Gulcin
dc.contributor.authorYilmaz, Dervis
dc.contributor.authorAral, Levent
dc.contributor.authorGultekin, Sibel Elif
dc.contributor.authorEroglu, Tamer
dc.contributor.authorKilic, Emine
dc.contributor.authorUckan, Sina
dc.date.accessioned2019-09-13T08:49:04Z
dc.date.available2019-09-13T08:49:04Z
dc.date.issued2016
dc.identifier.issn1678-7757
dc.identifier.urihttp://www.scielo.br/pdf/jaos/v24n1/1678-7757-jaos-24-1-0067.pdf
dc.identifier.urihttp://hdl.handle.net/11727/3908
dc.description.abstractAn increasing body of evidence suggests that the use of probiotic bacteria is a promising intervention approach for the treatment of inflammatory diseases with a polymicrobial etiology. P. gingivalis has been noted to have a different way of interacting with the innate immune response of the host compared to other pathogenic bacteria, which is a recognized feature that inhibits CXCL8 expression. Objective The aim of the study was to determine if P. gingivalis infection modulates the inflammatory response of gingival stromal stem cells (G-MSSCs), including the release of CXCL8, and the expression of TLRs and if immunomodulatory L. rhamnosus ATCC9595 could prevent CXCL8 inhibition in experimental inflammation. Material and Methods G-MSSCs were pretreated with L. rhamnosus ATCC9595 and then stimulated with P. gingivalis ATCC33277. CXCL8 and IL-10 levels were investigated with ELISA and the TLR-4 and 2 were determined through flow cytometer analysis. Results CXCL8 was suppressed by P. gingivalis and L. rhamnosus ATCC9595, whereas incubation with both strains did not abolish CXCL8. L. rhamnosus ATCC9595 scaled down the expression of TLR4 and induced TLR2 expression when exposed to P. gingivalis stimulation (p<0.01). Conclusions These findings provide evidence that L. rhamnosus ATCC9595 can modulate the inflammatory signals and could introduce P. gingivalis to immune systems by inducing CXCL8 secretion.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1590/1678-775720150145en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCXCL8 chemokineen_US
dc.subjectStromaen_US
dc.subjectPeriodontitisen_US
dc.subjectProbioticsen_US
dc.subjectReceptoren_US
dc.titleLactobacillus rhamnosus could inhibit Porphyromonas gingivalis derived CXCL8 attenuationen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF APPLIED ORAL SCIENCEen_US
dc.identifier.volume24en_US
dc.identifier.issue1en_US
dc.identifier.startpage67en_US
dc.identifier.endpage75en_US
dc.identifier.wos000375084600010


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record