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dc.contributor.authorSolmaz, Soner
dc.contributor.authorKorur, Asli
dc.contributor.authorGereklioglu, Cigdem
dc.contributor.authorAsma, Suheyl
dc.contributor.authorBuyukkurt, Nurhilal
dc.contributor.authorKasar, Mutlu
dc.contributor.authorYeral, Mahmut
dc.contributor.authorKozanoglu, Ilknur
dc.contributor.authorBoga, Can
dc.contributor.authorOzdogu, Hakan
dc.date.accessioned2019-09-18T10:32:16Z
dc.date.available2019-09-18T10:32:16Z
dc.date.issued2016
dc.identifier.issn2035-3006
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771136/
dc.identifier.urihttp://hdl.handle.net/11727/3949
dc.description.abstractBackground: Neutropenic patients are susceptible to any anorectal disease, and symptomatic anorectal disease afflicts 2-32% of oncology patients. Perianal infections are the most feared complication, considering the lack of natural defense against infectious microorganisms. When septic complications develop, the anorectal disease is potentially fatal, especially in neutropenic patients in whom mortality rates range between 11-57%. Although anorectal diseases are a frequent complication with potentially fatal outcomes among patients with hematologic diseases, sufficient data are not available in the literature. In this study, we aimed to investigate the anorectal complications developing during the neutropenic period in patients with hematologic diseases. Methods: A total of 79 patients whose neutropenic period (absolute neutrophil count < 500/mcL) continued for 7 days, or longer were included in the study. Results: A total of 34 patients out of 79 (43%) were detected to develop anorectal complications, of them 6 (7.6%) developed an anorectal infection. The patients were characterized according to the hematological disease and its status (active or not), the type of treatment and the presence of a history of an anorectal pathology before the onset of the hematologic disease. Nineteen (24.1%) patients had the history of anorectal disturbances before diagnosis of the hematologic disease, and recurrence of an anorectal pathology was found in 14 out of 19 patients(73.7%). In addition, the overall mortality rate was higher among the patients who developed anorectal complications compared to another group (41.2% vs. 22.2%, p= 0.059). Conclusion: Anorectal pathology is a common complication with high recurrence rate in neutropenic patients. Perianal infections are important as they can cause life-threatening outcomes although they are relatively rare among all anorectal complications. Therefore perianal signs and symptoms should be meticulously evaluated concerning early diagnosis and treatment.en_US
dc.language.isoengen_US
dc.relation.isversionof10.4084/MJHID.2016.019en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectINFECTIONSen_US
dc.titleAnorectal Complications During Neutropenic Period in Patients with Hematologic Diseasesen_US
dc.typearticleen_US
dc.relation.journalMEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASESen_US
dc.identifier.volume8en_US
dc.identifier.wos000371158800002


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