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dc.contributor.authorEkici, Yahya
dc.contributor.authorAkcay, Eda Yilmaz
dc.contributor.authorMoray, Gokhan
dc.date.accessioned2019-10-06T11:17:17Z
dc.date.available2019-10-06T11:17:17Z
dc.date.issued2015
dc.identifier.issn0020-8868
dc.identifier.urihttps://pinnacle.allenpress.com/doi/pdf/10.9738/INTSURG-D-15-00085.1
dc.identifier.urihttp://hdl.handle.net/11727/4052
dc.description.abstractColonic anastomotic leakage is still a problem in general surgery practice. We sought to investigate the effect of a new tissue adhesive, BioGlue, on the healing of normal and impaired colonic anastomoses. Sixty-four rats were randomized into 4 groups. In all animals, a 1-cm segment of the left colon was resected, and an end-to-end sutured anastomosis was created. Animals were then divided into 2 groups: normal and impaired anastomosis. These 2 groups were further subdivided into 2 additional groups: animals that received BioGlue and those that did not. All rats received intraperitoneal injections of either 0.9% NaCl or 5-fluorouracil (5-FU). Anastomotic evaluation was done 7 days after surgery. Macroscopic healing, mechanical strength, and histopathologic healing parameters were evaluated. Leakage of the anastomosis was significantly higher in rats in the impaired group compared with those in the BioGlue groups (P = 0.043). The adhesion formation score was significantly higher in rats in the impaired anastomosis group compared with the other groups. Bursting pressures were significantly lower in the impaired anastomosis group than in the other ones (P = 0.001). Neoangiogenesis and fibroblast activity were different among the groups (P = 0.001). Inflammatory cell infiltration and collagen deposition did not differ among the groups (P = 0.07). Immediate postoperative intraperitoneal administration of 5-FU after colonic anastomosis inhibits intestinal wound healing. Covering colon anastomoses with BioGlue after suturing conferred beneficial effect on healing.en_US
dc.language.isoengen_US
dc.relation.isversionof10.9738/INTSURG-D-15-00085.1en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectWound healingen_US
dc.subjectColon anastomosisen_US
dc.subjectBioGlueen_US
dc.subject5-Fluorouracilen_US
dc.titleEffect of the Bioadhesive, BioGlue, on Impaired Colonic Anastomose Healing in Ratsen_US
dc.typearticleen_US
dc.relation.journalINTERNATIONAL SURGERYen_US
dc.identifier.volume100en_US
dc.identifier.issue11-12en_US
dc.identifier.startpage1375en_US
dc.identifier.endpage1381en_US
dc.identifier.wos000212851100005


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