Biochemical and Histopathological Effects of Catechin on Experimental Peripheral Nerve Injuries
dc.contributor.author | Yildirim, Ali Erdem | |
dc.contributor.author | Dalgic, Ali | |
dc.contributor.author | Divanlioglu, Denizhan | |
dc.contributor.author | Akdag, Rifat | |
dc.contributor.author | Cetinalp, Nuri Eralp | |
dc.contributor.author | Alagoz, Fatih | |
dc.contributor.author | Helvacioglu, fatma | |
dc.contributor.author | Take, Gulnur | |
dc.contributor.author | Guvenc, Yahya | |
dc.contributor.author | Koksal, Ismet | |
dc.contributor.author | Belen, Ahmed Deniz | |
dc.date.accessioned | 2019-11-27T12:26:32Z | |
dc.date.available | 2019-11-27T12:26:32Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1019-5149 | |
dc.identifier.uri | http://turkishneurosurgery.org.tr/pdf/pdf_JTN_1530.pdf | |
dc.identifier.uri | http://hdl.handle.net/11727/4265 | |
dc.description.abstract | AIM: Catechin is a type of polyphenol, along with epicatechin, epigallocatechin, and epigallocatechin-gallate (EGCG). This study aims to investigate the effect of EGCG, a major metabolite of catechin, which is the principle bioactive compound in green tea, on rats with peripheral nerve injury. MATERIAL and METHODS: A total of 74 rats were divided into six groups, namely the control, the trauma, the normal saline, a 25mg/kg EGCG, a 50mg/kg EGCG and a daily consumption group (10mg/kg EGCG was given intraperitoneally for 14 days before the trauma). Except the first group, the other groups underwent a 1-minute sciatic nerve compression by clip with 50gr/cm(2) pressure. Nerve samples were obtained at 28 day after trauma for the biochemical and histopathological analysis. RESULTS: Our study showed that the Daily consumption, 25mg/kg EGCG and 50mg/kg EGCG groups demonstrated statistically significant decreased lipid peroxidation levels and particularly daily consumption, and the 25mg/kg EGCG group showed a favourable reduction of degeneration and edema histologically. CONCLUSION:This study shows that Catechin and its derivatives have a protective effect on peripheral nerve injury. | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | 10.5137/1019-5149.JTN.12852-14.2 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Axonal degeneration | en_US |
dc.subject | Epigallocatechin-gallate | en_US |
dc.subject | Electron microscope | en_US |
dc.subject | Light microscope | en_US |
dc.subject | Lipid peroxidation | en_US |
dc.subject | Peripheral nerve injury | en_US |
dc.title | Biochemical and Histopathological Effects of Catechin on Experimental Peripheral Nerve Injuries | en_US |
dc.type | article | en_US |
dc.relation.journal | TURKISH NEUROSURGERY | en_US |
dc.identifier.volume | 25 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 453 | en_US |
dc.identifier.endpage | 460 | en_US |
dc.identifier.wos | 000357065100015 | en_US |
dc.identifier.scopus | 2-s2.0-84930750395 | en_US |
dc.contributor.pubmedID | 26037187 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | en_US |
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