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dc.contributor.authorSezer, Siren
dc.contributor.authorUyar, Mehtap Erkmen
dc.contributor.authorTutal, Emre
dc.contributor.authorBal, Zeynep
dc.contributor.authorGuliyev, Orhan
dc.contributor.authorColak, Turan
dc.contributor.authorHasdemir, Efe
dc.contributor.authorHaberal, Mehmet
dc.date.accessioned2019-12-04T15:39:34Z
dc.date.available2019-12-04T15:39:34Z
dc.date.issued2015
dc.identifier.issn2314-6745
dc.identifier.urihttp://downloads.hindawi.com/journals/jdr/2015/293896.pdf
dc.identifier.urihttp://hdl.handle.net/11727/4309
dc.description.abstractBackground. New-onset diabetes after transplantation (NODAT) is associated with decreased graft survival and an increased risk for cardiovascular disease. The objective of this study was to evaluate the risk factors for development of NODAT and its' relationship with arterial stiffness and left ventricular mass index (LVMI) in kidney transplant recipients. Methods. 159 kidney transplant recipients were selected from our transplantation center who underwent renal transplantation between years 2007 and 2010. Results. Among 159 patients, 57 (32.2%) patients were with NODAT who were significantly older than patients without diabetes (P: 0.0001). Patients with NODAT had significantly higher pulse wave velocity (PWv) (P: 0.033) and left ventricular mass index LVMI (P: 0.001) compared to patients without NODAT. Further analysis was done according to LVMI as follows: LVMI > 130 g/m(2) (n: 57) and LVMI <= 130 g/m(2) (n: 102). We observed higher office systolic and diastolic BP, serum trygliceride, glucose, creatinine, age, and HbA1c (P: 0.0001) levels in patients with LVMI > 130 g/m(2). Linear regression analysis revealed that HbA1c was the major determinant of LVMI (P: 0.026, beta: 0.361). Conclusions. HbA1c is the major determinant of LVMI, so strict control of serum glucose levels is essential for preventing cardiovascular disease in patients with NODAT.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1155/2015/293896en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCARDIOVASCULAR RISK-FACTORSen_US
dc.subjectAORTIC PULSE-WAVEen_US
dc.subjectKIDNEY-TRANSPLANTATIONen_US
dc.subjectARTERIAL STIFFNESSen_US
dc.subjectALLOGRAFT RECIPIENTSen_US
dc.subjectINSULIN-RESISTANCEen_US
dc.subjectCARDIAC STRUCTUREen_US
dc.subjectBLOOD-PRESSUREen_US
dc.subjectMELLITUSen_US
dc.subjectIMPACTen_US
dc.titleNew-Onset Diabetes and Glucose Regulation Are Significant Determinants of Left Ventricular Hypertrophy in Renal Transplant Recipientsen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF DIABETES RESEARCHen_US
dc.identifier.wos000353139800001


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