Variations in apparent diffusion coefficient values following chemotherapy in pediatric neuroblastoma
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Tarih
2015Yazar
Demir, Senay
Altinkaya, Naime
Kocer, Nazim Emrah
Erbay, Ayse
Oguzkurt, Pelin
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PURPOSE
In children the assessment of solid tumors' response to chemotherapy is based primarily on size reduction, which can be unreliable and a late marker, in the presence of necrosis. We aimed to establish whether apparent diffusion coefficient (ADC) values of childhood neuroblastomas show proportional changes in relation to chemotherapy response.
METHODS
We evaluated 15 pediatric patients with abdominopelvic neuroblastomas, who had undergone MRI before and after chemotherapy. Two radiologists retrospectively analyzed all images by drawing a round uniform region-of-interest in the solid/contrast-enhancing portion of the lesions in consensus. The ADC values from pre- and postchemotherapy images were compared. RESULTS Postchemotherapy ADC values were significantly higher than those obtained before treatment (P < 0.05, for minimum, maximum, and median ADC values).
CONCLUSION
Our results support diffusion-weighted MRI as a promising noninvasive biomarker of therapeutic responses. To the best of our knowledge, this is the first report to compare diffusion-weighted imaging findings before and after chemotherapy in childhood neuroblastic tumors.
Bağlantı
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4463315&blobtype=pdfhttp://hdl.handle.net/11727/4326
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