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dc.contributor.authorOzcurumez, Gamze
dc.contributor.authorYurdakul, Hasan Talha
dc.contributor.authorTerzi, Yunus
dc.contributor.authorDirek, Nese
dc.contributor.authorEssizoglu, Altan
dc.contributor.authorSahin, Feride
dc.date.accessioned2020-07-28T12:59:46Z
dc.date.available2020-07-28T12:59:46Z
dc.date.issued2019
dc.identifier.issn1300-0667en_US
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563855/
dc.identifier.urihttp://hdl.handle.net/11727/4801
dc.description.abstractIntroduction: There is inconsistent evidence of interaction between childhood adversities and a serotonin transporter promoter polymorphism (5- HTTLPR) in depression. It is hypothesized that genetic sensitivity to stress could be more specific to recurrent major depressive disorder (MDD). The aim of the study is to replicate a recent study which provided preliminary evidence of interaction between severity of childhood maltreatment and the 5-HTTLPR polymorphism in recurrent MDD. Methods: Participants included a well-characterized clinical sample of 70 recurrent MDD cases and 67 never psychiatrically ill controls, aged 18 years or over. Socio-demographic and clinical information form, Composite International Diagnostic Interview (CIDI), Childhood Trauma Questionnaire (CTQ), Beck Depression Inventory (BDI) were applied to both groups, along with genotyping. Results: There was no interaction between childhood maltreatment and the 5-HTTLPR in relation to recurrent MDD. All forms of childhood maltreatment were reported as more severe by cases than controls, and there was an independent association between maltreatment and recurrent MDD. Conclusion: The path forward to detect genetic risk loci for depression remains challenging. Taking childhood maltreatment history into account could lead to a richer understanding of differences in biological correlates, genetic underpinnings, and outcomes.en_US
dc.language.isoengen_US
dc.relation.isversionof10.29399/npa.23325en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRecurrent depressionen_US
dc.subjectchildhood maltreatmenten_US
dc.subject5-HTTLPRen_US
dc.titleNo Interaction Between Childhood Maltreatment and Serotonin Transporter Gene in Recurrent Major Depressive Disorder: A Clinical Sampleen_US
dc.typearticleen_US
dc.relation.journalNOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRYen_US
dc.identifier.volume56en_US
dc.identifier.issue2en_US
dc.identifier.startpage110en_US
dc.identifier.endpage114en_US
dc.identifier.wos000503182900006en_US
dc.identifier.scopus2-s2.0-85068741200en_US
dc.contributor.pubmedID31223242en_US
dc.contributor.orcID0000-0001-5612-9696en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.contributor.researcherIDB-4372-2018en_US


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