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dc.contributor.authorBeysel, Selvihan
dc.contributor.authorPinarli, Ferda Alparslan
dc.contributor.authorEyerci, Nilnur
dc.contributor.authorKizilgul, Muhammed
dc.contributor.authorHepsem, Sema
dc.contributor.authorAlhan, Ali
dc.contributor.authorKan, Seyfullah
dc.contributor.authorCaliskan, Mustafa
dc.contributor.authorBozkurt, Erhan
dc.contributor.authorCakal, Erman
dc.date.accessioned2020-10-09T06:47:48Z
dc.date.available2020-10-09T06:47:48Z
dc.date.issued2019
dc.identifier.issn0951-3590en_US
dc.identifier.urihttp://hdl.handle.net/11727/4834
dc.description.abstractThe association of the FTO gene and HNF1 alpha gene on gestational diabetes mellitus (GDM) and preeclampsia remains unclear. This is the first study to examine whether HNF1 alpha gene and FTO gene were associated with having GDM and preeclampsia in Turkish women. Healthy pregnant women (n = 101) and women with GDM (n = 169) were included. GDM was divided into two groups as GDM-only (n = 90) and GDM-preeclampsia (n = 79). Genotyping of HNF1 alpha gene p.I27L, p.A98V, and p.S487N, and FTO gene rs9939609 SNPs were performed using RT-PCR. The frequency of p.S487N, p.A98V, and FTO genotype were similar between the groups (p > .05). p.I27L GG-wild, GT, and TT genotype were 56.5%, 36.6%, and 6.9% in controls; 40.0%, 51.1%, and 8.9% in GDM-only; and 26.6%, 51.9%, and 21.5% in GDM-preeclampsia (p = .034). TT and GT genotype was more frequent in GDM-preeclampsia than in controls (p < .05). GT genotype was increased in GDM-only compared with controls (p < .05). TT genotype was more frequent in GDM-preeclampsia than in GDM-only (p < .05). p.I27L TT genotype was independently associated with increased blood pressure (BP) and urinary protein. p.I27L TT genotype was associated with increased preeclampsia risk in patients with GDM by increasing BP and urinary protein.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1080/09513590.2019.1698023en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHNF1 alphaen_US
dc.subjectFTOen_US
dc.subjectpen_US
dc.subjectI27Len_US
dc.subjectpreeclampsiaen_US
dc.subjectgestational diabetesen_US
dc.titleHNF1A gene p.I27L is associated with co-existing preeclampsia in gestational diabetes mellitusen_US
dc.typearticleen_US
dc.relation.journalGYNECOLOGICAL ENDOCRINOLOGYen_US
dc.identifier.volume36en_US
dc.identifier.issue6en_US
dc.identifier.startpage530en_US
dc.identifier.endpage534en_US
dc.identifier.wos000501968600001en_US
dc.identifier.scopus2-s2.0-85076435055en_US
dc.contributor.pubmedID31825269en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US


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