Management of Kaposi sarcoma after solid organ transplantation: A European retrospective study
Tarih
2019Yazar
Delyon, Julie
Rabate, Clementine
Euvrard, Sylvie
Harwood, Catherine A.
Proby, Charlotte
Gulec, Tulin
Seckin, Deniz
Del Marmol, Veronique
Bouwes-Bavinck, Jan Nico
Ferrandiz-Pulido, Carla
Ocampo, Maria Andrea
Barete, Stephane
Legendre, Christophe
Frances, Camille
Porcher, Raphael
Lebbe, Celeste
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Background: Systemic therapeutic management of post-transplant Kaposi sarcoma (KS) is mainly based on 3 axes: reduction of immunosuppression, conversion to mammalian target of rapamycin (mTOR) inhibitors, chemotherapy, or a combination of these.
Objective: To obtain an overview of clinical strategies about the current treatment of KS.
Methods: We conducted a multicenter retrospective cohort study including 145 solid organ transplant recipients diagnosed with KS between 1985 and 2011 to collect data regarding first-line treatment and response at 6 months.
Results: Overall, 95%, 28%, and 16% of patients had reduction of immunosuppression, conversion to mTOR inhibitor, and chemotherapy, respectively. Patients treated with chemotherapy or mTOR inhibitor conversion were more likely to have visceral KS. At 6 months, 83% of patients had response, including 40% complete responses.
Limitations: The retrospective design of the study.
Conclusion: Currently available therapeutic options seem to be effective to control KS in most patients. Tapering down the immunosuppressive regimen remains the cornerstone of KS management.