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dc.contributor.authorErsoy, Zeynep Girgin
dc.contributor.authorKayihan, Ceyhun
dc.contributor.authorTunca, Sedef
dc.date.accessioned2021-08-17T13:39:56Z
dc.date.available2021-08-17T13:39:56Z
dc.date.issued2020
dc.identifier.issn1517-8382en_US
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455682/
dc.identifier.urihttp://hdl.handle.net/11727/6285
dc.description.abstractThere are different studies that aim to enhance the production of nisin by Lactococcus lactis since its chemical synthesis is not possible. In this study, glutathione (GSH) and pyruvate, which are known to reduce the oxidative stress of cells, have been shown to trigger the production of nisin at both transcriptional and translational levels in L. lactis cells grown under aerobic condition. Presence of GSH and pyruvate caused more nisin yield than the heme-supplemented medium. Moreover, the expression of genes that encode stress-related enzymes were apparently upregulated in the presence of GSH and pyruvate. It can be concluded that GSH and pyruvate contribute to the defense system of L. lactis cells and so that higher biomass was obtained which in turn enhance nisin production. Antioxidant effect of GSH and pyruvate was known; however, their stimulating effect on nisin production was shown for the first time in this study.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1007/s42770-019-00216-wen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGlutathioneen_US
dc.subjectLactococcus lactisen_US
dc.subjectNisin productionen_US
dc.subjectOxidative stressen_US
dc.subjectPyruvateen_US
dc.titleHigher nisin yield is reached with glutathione and pyruvate compared with heme in Lactococcus lactis N8en_US
dc.typearticleen_US
dc.relation.journalBRAZILIAN JOURNAL OF MICROBIOLOGYen_US
dc.identifier.volume51en_US
dc.identifier.issue3en_US
dc.identifier.startpage1247en_US
dc.identifier.endpage1257en_US
dc.identifier.wos000505377900002en_US
dc.identifier.scopus2-s2.0-85077632425en_US
dc.contributor.pubmedID31898248en_US
dc.contributor.orcID0000-0003-1684-4147en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.contributor.researcherIDQ-4515-2016en_US


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