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dc.contributor.authorSomay, Efsun
dc.contributor.authorYilmaz, Busra
dc.date.accessioned2022-08-08T10:47:00Z
dc.date.available2022-08-08T10:47:00Z
dc.date.issued2021
dc.identifier.issn1472-6831en_US
dc.identifier.urihttps://bmcoralhealth.biomedcentral.com/track/pdf/10.1186/s12903-021-01899-0.pdf
dc.identifier.urihttp://hdl.handle.net/11727/7265
dc.description.abstractBackground The systemic immune-inflammation index (SII) has been demonstrated to be a valid biomarker of a patient's immunological and inflammatory state, with the ability to accurately predict outcomes in a variety of disease conditions. In the absence of comparable studies, we intended to examine the relevance of pretreatment SII in predicting the success rates of temporomandibular joint arthrocentesis (TMJA) at 1-week, 1-month, and 6-month periods, defined as maximum mouth opening (MMO) > 35 mm and VAS <= 3. Methods A sum of 136 patients with disc displacement without reduction (DDwo-red) who underwent TMJA was included. For each patient, pre-TMJA SII was calculated as; SII = Platelets x neutrophils/lymphocytes. Additionally, baseline MMO and VAS measurements were recorded for each patient. The success criteria of TMJA included MMO > 35 mm and VAS <= 3. The optimal pre-TMJA SII cutoff that predicts TMJA success was determined using receiver operating characteristic (ROC) curve analysis. The primary endpoint was the link between the pre-treatment SII and TMJA success (simultaneous achievement of MMO > 35 mm and VAS <= 3). Results The median pre-TMJA jaw locking duration, maximum mouth opening (MMO), and visual analog score (VAS) were 7 days, 24 mm, and 8, respectively. The overall TMJA success rates were determined as 80.1%, 91.9%, and 69.1% at 1-week, 1-month, and 6-months, respectively. The results of ROC curve analysis exhibited the optimal SII cutoff at 526 (AUC: 67.4%; sensitivity: 66.7%; specificity: 64.2%) that grouped the patients into two subgroups: Group 1: SII <= 526 (N = 81) and SII > 526 (N = 55), respectively. Spearman correlation analysis revealed a strong inverse relationship between the pretreatment SII values and the success of TMJA 1-week (r(s): - 0.83; P = 0.008) and 1-month, (r(s): - 0.89; P = 0.03). Comparative analyses displayed that TMJA success rates at 1-week (87.7% vs. 69.1%; P = 0.008) and 1-month (96.2% vs. 80%; P = 0.03) were significantly higher in the SII <= 526 than SII > 526 group, respectively, while the 6-month results favored the SII <= 526 group with a trend approaching significance (P = 0.084). Conclusion The current study's findings suggested the SII as a unique independent prognostic biomarker that accurately predicts treatment outcomes for up to 6 months. Trial registration The results of this research were retrospectively registered.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1186/s12903-021-01899-0en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTemporomandibular joint arthrocentesisen_US
dc.subjectSystemic immune-inflammation indexen_US
dc.subjectTemporomandibular joint disorderen_US
dc.subjectBiomarkeren_US
dc.subjectSuccessen_US
dc.titleHigh pretreatment systemic immune-inflammation index values are associated with diminished short-term success after temporomandibular joint arthrocentesis procedureen_US
dc.typearticleen_US
dc.relation.journalBMC ORAL HEALTHen_US
dc.identifier.volume21en_US
dc.identifier.issue1en_US
dc.identifier.startpage1en_US
dc.identifier.endpage9en_US
dc.identifier.wos000707576300003en_US
dc.identifier.scopus2-s2.0-85117284558en_US
dc.contributor.pubmedID34654426en_US
dc.contributor.orcID0000-0003-0633-5648en_US
dc.contributor.orcID0000-0001-8251-6913en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US


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