dc.contributor.author | Akilli, Huseyin | |
dc.contributor.author | Celik, Husnu | |
dc.contributor.author | Ayhan, Ali | |
dc.date.accessioned | 2022-08-09T06:50:38Z | |
dc.date.available | 2022-08-09T06:50:38Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0022-4790 | en_US |
dc.identifier.uri | http://hdl.handle.net/11727/7285 | |
dc.description.abstract | Background and Objectives Evaluating nodal metastases in low-grade serous ovarian cancer (LGSOC) patients. Methods Women with LGSOC who had undergone primary cytoreductive surgery comprising systematic pelvic-paraaortic lymphadenectomy were included. Data were obtained retrospectively from 12 oncology centers. Results One hundred and forty-eight women with LGSOC who had undergone comprehensive surgical staging were included. Seventy-one (48.0%) patients had metastatic lymph nodes. Preoperative serum CA-125 levels of >= 170 U/ml (odds ratio [OR]: 3.84; 95% confidence interval [CI]: 1.22-12.07; p = 0.021) and presence of lymphovascular space invasion (LVSI) (OR: 13.72; 95% CI: 3.36-55.93; p < 0.001) were independent predictors of nodal metastasis in LGSOC. Sixty (40.5%) patients were classified to have apparently limited disease to the ovary/ovaries. Twenty (33.3%) of them were upstaged after surgical staging. Twelve (20.0%) had metastatic lymph nodes. Presence of LVSI (OR: 12.96; 95% CI: 1.14-146.43; p = 0.038) and preoperative serum CA-125 of >= 180 U/ml (OR: 7.19; 95% CI: 1.35-38.12; p = 0.02) were independent predictors of lymph node metastases in apparent Stage I disease. Conclusions Clinicians may consider to perform a reoperation comprising systematic lymphadenectomy in patients who had apparently limited disease to the ovary/ovaries and had not undergone lymphadenectomy initially. Reoperation may be considered particularly in patients whose preoperative serum CA-125 is >= 180 U/ml and/or whose pathological assessment reported the presence of LVSI. | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | 10.1002/jso.26700 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | low-grade | en_US |
dc.subject | lymphadenectomy | en_US |
dc.subject | metastasis | en_US |
dc.subject | ovarian cancer | en_US |
dc.subject | serous | en_US |
dc.title | Factors associated with the involvement of lymph nodes in low-grade serous ovarian cancer | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF SURGICAL ONCOLOGY | en_US |
dc.identifier.volume | 125 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 264 | en_US |
dc.identifier.endpage | 272 | en_US |
dc.identifier.wos | 000704198700001 | en_US |
dc.identifier.scopus | 2-s2.0-85116389648 | en_US |
dc.contributor.pubmedID | 34610148 | en_US |
dc.contributor.orcID | 0000-0002-5240-8441 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | en_US |
dc.contributor.researcherID | AAX-3230-2020 | en_US |