dc.contributor.author | Cinar, Bekir Murat | |
dc.contributor.author | Battal, Vahit Erdal | |
dc.contributor.author | Bal, Nebil | |
dc.contributor.author | Guler, Umit Ozgur | |
dc.contributor.author | Beyaz, Salih | |
dc.date.accessioned | 2022-11-22T12:28:43Z | |
dc.date.available | 2022-11-22T12:28:43Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 1017-995X | en_US |
dc.identifier.uri | https://www.aott.org.tr/en/comparison-of-efficacy-of-oral-versus-intra-articular-corticosteroid-application-in-the-treatment-of-frozen-shoulder-an-experimental-study-in-rats-168196 | |
dc.identifier.uri | http://hdl.handle.net/11727/8145 | |
dc.description.abstract | Objective: The aim of this study was to compare clinical and histopathological effects of oral versus intraarticular corticosteroid application in a rat model of frozen shoulder.
Methods: In this study, eighty adult Sprague-Dawley rats were used. The animals were divided into 5 equal groups. The frozen shoulder model was created by immobilizing animals' shoulders with internal fixation with sutures for 8 weeks. At the 8th week, sham(n: 16) and control (n: 16) groups were sacrificed to collect data for healthy and affected shoulders. Also, at the 8th week, 50 mg/kg methylprednisolone was started for the oral treatment group, and a single dose of 0.5mg/kg triamcinolone acetonide was injected for the intraarticular treatment group. The effect of additional steroid treatment was expected for 2 weeks, then all remaining treatment and natural course groups were sacrificed on the 10th week.
Results: After sacrification, specimens taken as "en bloc" scapulothoracic disarticulation were randomly divided into two groups for a range of motion measurement and histopathological examination. The control (frozen shoulder model) group's shoulder range of motion in all directions was lower than the sham (healthy) group (P < 0.01). Natural course and intraarticular steroid groups, compared to the frozen shoulder model showed a significant increase in the direction of abduction (P < 0.05). Also, it was found for treatment groups that in all directions the range of motion was not as good as the healthy values (P < 0.01). The intraarticular treatment group showed higher degrees of abduction compared to the natural course and oral steroid treatment groups (P < 0.01). Oral steroid treatment group's range of motion was not significantly better than the disease model and had no superiority to the natural course group (P > 0.05). Histopathologically, no statistically significant difference was observed between the groups for signs of frozen shoulder which was found in the immobilized group (P > 0.05). Histopathologically, immobilization was found to cause thickening of the capsule that cannot be resolved by treatment. (P < 0.05).
Conclusion: In frozen shoulder disease, intraarticular steroid injection seems to be superior in increasing the range of motion than oral steroid treatment. | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | 10.5152/j.aott.2021.20332 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Frozen shoulder | en_US |
dc.subject | Adhesive capsulitis | en_US |
dc.subject | Corticosteroid | en_US |
dc.subject | Animal model | en_US |
dc.title | Comparison Of Efficacy Of Oral Versus Intra-Articular Corticosteroid Application In The Treatment Of Frozen Shoulder: An Experimental Study In Rats | en_US |
dc.type | article | en_US |
dc.relation.journal | ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA | en_US |
dc.identifier.volume | 56 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 64 | en_US |
dc.identifier.endpage | 70 | en_US |
dc.identifier.wos | 000767118100013 | en_US |
dc.identifier.scopus | 2-s2.0-85125557395 | en_US |
dc.contributor.pubmedID | 35234132 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | en_US |