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dc.contributor.authorCinar, Bekir Murat
dc.contributor.authorBattal, Vahit Erdal
dc.contributor.authorBal, Nebil
dc.contributor.authorGuler, Umit Ozgur
dc.contributor.authorBeyaz, Salih
dc.date.accessioned2022-11-22T12:28:43Z
dc.date.available2022-11-22T12:28:43Z
dc.date.issued2022
dc.identifier.issn1017-995Xen_US
dc.identifier.urihttps://www.aott.org.tr/en/comparison-of-efficacy-of-oral-versus-intra-articular-corticosteroid-application-in-the-treatment-of-frozen-shoulder-an-experimental-study-in-rats-168196
dc.identifier.urihttp://hdl.handle.net/11727/8145
dc.description.abstractObjective: The aim of this study was to compare clinical and histopathological effects of oral versus intraarticular corticosteroid application in a rat model of frozen shoulder. Methods: In this study, eighty adult Sprague-Dawley rats were used. The animals were divided into 5 equal groups. The frozen shoulder model was created by immobilizing animals' shoulders with internal fixation with sutures for 8 weeks. At the 8th week, sham(n: 16) and control (n: 16) groups were sacrificed to collect data for healthy and affected shoulders. Also, at the 8th week, 50 mg/kg methylprednisolone was started for the oral treatment group, and a single dose of 0.5mg/kg triamcinolone acetonide was injected for the intraarticular treatment group. The effect of additional steroid treatment was expected for 2 weeks, then all remaining treatment and natural course groups were sacrificed on the 10th week. Results: After sacrification, specimens taken as "en bloc" scapulothoracic disarticulation were randomly divided into two groups for a range of motion measurement and histopathological examination. The control (frozen shoulder model) group's shoulder range of motion in all directions was lower than the sham (healthy) group (P < 0.01). Natural course and intraarticular steroid groups, compared to the frozen shoulder model showed a significant increase in the direction of abduction (P < 0.05). Also, it was found for treatment groups that in all directions the range of motion was not as good as the healthy values (P < 0.01). The intraarticular treatment group showed higher degrees of abduction compared to the natural course and oral steroid treatment groups (P < 0.01). Oral steroid treatment group's range of motion was not significantly better than the disease model and had no superiority to the natural course group (P > 0.05). Histopathologically, no statistically significant difference was observed between the groups for signs of frozen shoulder which was found in the immobilized group (P > 0.05). Histopathologically, immobilization was found to cause thickening of the capsule that cannot be resolved by treatment. (P < 0.05). Conclusion: In frozen shoulder disease, intraarticular steroid injection seems to be superior in increasing the range of motion than oral steroid treatment.en_US
dc.language.isoengen_US
dc.relation.isversionof10.5152/j.aott.2021.20332en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFrozen shoulderen_US
dc.subjectAdhesive capsulitisen_US
dc.subjectCorticosteroiden_US
dc.subjectAnimal modelen_US
dc.titleComparison Of Efficacy Of Oral Versus Intra-Articular Corticosteroid Application In The Treatment Of Frozen Shoulder: An Experimental Study In Ratsen_US
dc.typearticleen_US
dc.relation.journalACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICAen_US
dc.identifier.volume56en_US
dc.identifier.issue1en_US
dc.identifier.startpage64en_US
dc.identifier.endpage70en_US
dc.identifier.wos000767118100013en_US
dc.identifier.scopus2-s2.0-85125557395en_US
dc.contributor.pubmedID35234132en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US


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