Characteristics And Outcomes Of Carbapenemase Harbouring Carbapenem-Resistant Klebsiella Spp. Bloodstream Infections: A Multicentre Prospective Cohort Study In An OXA-48 Endemic Setting
Tarih
2022Yazar
Isler, Burcu
Ozer, Berna
Cinar, Gule
Aslan, Abdullah Tarik
Vatansever, Cansel
Falconer, Caitlin
Dolapci, Istar
Simsek, Funda
Tulek, Necla
Demirkaya, Hamiyet
Menekse, Sirin
Akalin, Halis
Balkan, Ilker Inanc
Aydin, Mehtap
Tigen, Elif Tukenmez
Demir, Safiye Koculu
Kapmaz, Mahir
Keske, Siran
Dogan, Ozlem
Arabaci, Cigdem
Yagci, Serap
Hazirolan, Gulsen
Bakir, Veli Oguzalp
Gonen, Mehmet
Chatfield, Mark D.
Forde, Brian
Saltoglu, Nese
Azap, Alpay
Azap, Ozlem
Akova, Murat
Paterson, David L.
Can, Fusun
Ergonul, Onder
Üst veri
Tüm öğe kaydını gösterÖzet
A prospective, multicentre observational cohort study of carbapenem-resistant Klebsiella spp. (CRK) bloodstream infections was conducted in Turkey from June 2018 to June 2019. One hundred eighty-seven patients were recruited. Single OXA-48-like carbapenemases predominated (75%), followed by OXA-48-like/NDM coproducers (16%). OXA-232 constituted 31% of all OXA-48-like carbapenemases and was mainly carried on ST2096. Thirty-day mortality was 44% overall and 51% for ST2096. In the multivariate cox regression analysis, SOFA score and immunosuppression were significant predictors of 30-day mortality and ST2096 had a non-significant effect. All OXA-48-like producers remained susceptible to ceftazidime-avibactam.