Comparison Of Ceftazidime-Avibactam Susceptibility Testing Methods Against OXA-48-Like Carrying Klebsiella Blood Stream Isolates
Tarih
2022Yazar
Isler, Burcu
Vatansever, Cansel
Ozer, Berna
Cinar, Gule
Aslan, Abdullah Tarik
Stewart, Adam
Simos, Peter
Falconer, Caitlin
Bauer, Michelle J.
Forde, Brian
Harris, Patrick
Simsek, Funda
Tulek, Necla
Demirkaya, Hamiyet
Menekse, Sirin
Akalinj, Halis
Balkan, Ilker Inanc
Aydin, Mehtap
Tigen, Elif Tukenmez
Demir, Safiye Koculu
Kapmaz, Mahir
Keske, Siran
Dogan, Ozlem
Arabaci, Cigdem
Yagci, Serap
Hazirolan, Gulsen
Bakir, Veli Oguzalp
Gonen, Mehmet
Saltoglu, Nese
Azap, Alpay
Azap, Ozlem
Akova, Murat
Ergonul, Onder
Paterson, David L.
Can, Fusun
Üst veri
Tüm öğe kaydını gösterÖzet
Ceftazidime-avibactam exhibits good in vitro activity against carbapenem resistant Klebsiella carrying OXA-48-like enzymes. We tested two hundred unique carbapenem resistant Klebsiella blood stream isolates (71% with single OXA-48-like carbapenemases, including OXA-48, n = 62; OXA-232, n = 57; OXA-244, n = 17; OXA-181, n = 5) that were collected as part of a multicentre study against ceftazidime-avibactam using Etest (bioMerieux, Marcyl'Etoile, France), 10/4 mg disc (Thermo Fisher) and Sensititre Gram Negative EURGNCOL Plates (Lyophilized panels, Sensititre, Thermo Fisher) with the aim of comparing the performances of the Etest and disc to that of Sensititre. Ceftazidime-avibactam MIC50/90 was 2/> 16 mg/L for the entire collection and was 2/4 mg/L for single OXA-48-like producers. Categorical and essential agreements between the Etest and Sensititre were 100% and 97%, respectively. Categorical agreement between the disc and Sensititre was 100%. Etest and 10/4 mg discs are suitable alternatives to Sensititre for ceftazidime-avibactam sensitivity testing for OXA-48-like producers. (C) 2022 Elsevier Inc. All rights reserved.