Adenovirus-36 Infection and Obesity: A Case Control Study of Turkish Women with Polycystic Ovary Syndrome

Abstract

Background and aims: Adenovirus-36 (Ad-36) seropositivity has been shown to be involved in the aetiology of obesity. The aim of this study was to examine Ad-36 positivity in obese and normal-weight patients with polycystic ovary syndrome (PCOS).

Methods: There were two groups including 92 and 110 subjects. This study was a prospective casecontrol study. The enzyme-immunoassay method was used to quantitatively determine antibodies (Abs) specific to human Ad-36 in the serum samples. Age, body mass index (BMI), fasting glucose levels and insulin levels of the participants were recorded. The PCOS and control group patients were divided into two groups: the overweight group with BMI >= 25 kg/m(2) and non-obese group with BMI <25 kg/m(2).

Results: Ad-36 Ab positivity in the PCOS group was found to be significantly higher than that in the control group (p < 0.001). Ad-36 Ab positivity was significantly higher in the PCOS obese group than in the control obese group (p < 0.001). Ad-36 Ab positivity and BMI >= 25 kg/m(2) were identified as independent predictors of PCOS in logistic regression analysis.

Conclusion: Ad-36 Ab positivity was significantly higher in the obese/overweight PCOS patients. Obesity can be prevented in patients with PCOS by treating Ad-36. (C) 2021 Diabetes India. Published by Elsevier Ltd. All rights reserved.