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dc.contributor.authorKarabuga, Havva
dc.contributor.authorGultekin, Melis
dc.contributor.authorTulunay, Gokhan
dc.contributor.authorYuce, Kunter
dc.contributor.authorAyhan, Ali
dc.contributor.authorYuce, Deniz
dc.contributor.authorYildiz, Ferah
dc.date.accessioned2023-12-20T11:28:07Z
dc.date.available2023-12-20T11:28:07Z
dc.date.issued2015
dc.identifier.issn1048-891Xen_US
dc.identifier.urihttp://hdl.handle.net/11727/11142
dc.description.abstractObjective The current study evaluates long-term quality of life (QOL) and sexual function of patients with endometrial cancer who received adjuvant pelvic external beam radiotherapy (EBRT) and/or vaginal brachytherapy (BRT). Materials and Methods One hundred forty-four endometrial cancer survivors who were treated between January 2000 and December 2009 in our department were included in this study. Median follow-up was 79 months (range, 31-138 months). Fifty-two patients were treated with 45 to 50.4 Gy EBRT, 76 were with BRT, and 16 were with both EBRT and BRT. Brachytherapy was in the form of vaginal cuff BRT with 5 x 550 cGy high dose rate BRT, prescribed to the first 4 cm and whole wall thickness of vagina. Quality of life was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 and subscales from the supplemental 24-item Cervical Cancer Module. Results Vaginal BRT patients reported better physical functioning (P = 0.01), role functioning (P = 0.03), and sexual enjoyment (P = 0.01) compared to EBRT group. Symptom score (P = 0.01), lymphedema (P = 0.03), pain (P = 0.02), and diarrhea (P = 0.009) scores were also higher with EBRT. Vaginal BRT did not worsen symptom scores or sexual functions when added to EBRT. Obese patients experienced higher rates of lymphedema (P = 0.008). Cognitive and role functioning scores were significantly higher in patients with normal body mass index. Conclusions External beam radiotherapy negatively affects long-term QOL and sexual functions in endometrial cancer survivors. Vaginal BRT provides higher QOL. Patients with body mass index within normal limits have improved QOL.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1097/IGC.0000000000000509en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRadiotherapyen_US
dc.subjectEndometrial canceren_US
dc.subjectQuality of lifeen_US
dc.titleAssessing the Quality of Life in Patients with Endometrial Cancer Treated with Adjuvant Radiotherapyen_US
dc.typearticleen_US
dc.relation.journalINTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCERen_US
dc.identifier.volume25en_US
dc.identifier.issue8en_US
dc.identifier.startpage1526en_US
dc.identifier.endpage1533en_US
dc.identifier.wos000362177800027en_US
dc.identifier.scopus2-s2.0-84943189775en_US
dc.identifier.eissn1525-1438en_US
dc.contributor.pubmedID26207785en_US
dc.contributor.orcID0000-0003-0440-0725en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.contributor.researcherIDAAJ-5802-2021en_US


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