Yazar "Denkbas, Emir Baki" için Mühendislik Fakültesi / Faculty of Engineering listeleme
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Chondrogenesis of human mesenchymal stem cells by microRNA loaded triple polysaccharide nanoparticle system
Celik, Ekin; Bayram, Cem; Denkbas, Emir Baki (2019)Degenerative cartilage is the pathology of severe depletion of extracellular matrix components in articular cartilage. In diseases like osteoarthritis, misregulation of microRNAs contributes the pathology and collectively ... -
Designing siRNA-conjugated plant oil-based nanoparticles for gene silencing and cancer therapy
Anilmis, Nur Merve; Kara, Goknur; Kilicay, Ebru; Hazer, Baki; Denkbas, Emir Baki (2019)In this study, the anticancer activities of two siRNA carriers were compared using a human lung adenocarcinoma epithelial cell line (A549). Firstly, poly(styrene)-graft-poly(linoleic acid) (PS-g-PLina) and poly(styrene)- ... -
Development of Electrochemical Biosensor Platforms for Determination of Environmental Viral Structures
Ekici, Rumeysa; Bozdogan, Betul; Denkbas, Emir Baki (2022)Infectious diseases caused by viruses (such as influenza, Zika, human immunodeficiency, Ebola, dengue, hepatitis, and COVID-19 virus) are diseases that have been on the agenda of the whole world for the last quarter of a ... -
Development of novel poly-l-lysine-modified sericin-coated superparamagnetic iron oxide nanoparticles as siRNA carrier
Kara, Goknur; Malekghasemi, Soheil; Ozpolat, Bulent; Denkbas, Emir Baki (2021)Small interfering RNA (siRNA) is a promising therapeutic modality, however, its successful clinical application is still challenging due to the lack of safe and efficient carrier systems. Superparamagnetic iron oxide ... -
Effect of argon plasma and Er:YAG laser on tensile bond strength between denture liner and acrylic resin
Yildirim, Arzu Zeynep; Unver, Senem; Mese, Ayse; Bayram, Cem; Denkbas, Emir Baki; Cevik, Pinar (2020)Statement of problem. The separation of a denture liner from the denture base can be a clinical problem. Different surface treatments to increase the bond have been evaluated, but studies comparing the effect of argon ... -
Electrospun Nanofiber Reinforcement of Dental Composites with Electromagnetic Alignment Approach
Uyar, Tansel; Cokeliler, Dilek; Dugan, Mustafa; Kocum, Ismail Cengiz; Karatay, Okan; Denkbas, Emir Baki (2016)Polymethylmethacrylate (PMMA) is commonly used as a base acrylic denture material with benefits of rapid and easy handling, however, when it is used in prosthetic dentistry, fracturing or cracking problems can be seen due ... -
Magnetic Gelatin Nanoparticles As A Biocompatible Carrier System for Small Interfering RNA in Human Colorectal Cancer: Synthesis, Optimization, Characterization, and Cell Viability Studies
Selimovic, Amina; Kara, Goknur; Denkbas, Emir Baki (2022)Iron oxide-based nanoparticles have gained tremendous attention in developing next-generation personalized medicine modalities. Gelatin can be a good alternative for encapsulating iron oxide nanoparticles with its ... -
Magnetically responsive, sorafenib loaded alginate microspheres for hepatocellular carcinoma treatment
Alpdemir, Sukran; Vural, Tayfun; Kara, Goknur; Bayram, Cem; Haberal, Erdem; Denkbas, Emir Baki (2020)This study aimed to develop sorafenib loaded magnetic microspheres for the treatment of hepatocellular carcinoma. To achieve this goal, superparamagnetic iron oxide nanoparticles (SPIONs) were synthesised and encapsulated ... -
MiR-329 mimic based nano-therapy inhibits growth and progression of triple negative breast cancer
Kara, Goknur; Kahraman, Nermin; Denkbas, Emir Baki; Calin, George; Ozpolat, Bulent (2020) -
Porous polyurethane film fabricated via the breath figure approach for sustained drug release
Daha, Gizem; Bayram, Cem; Bozdogan, Betuel; Denkbas, Emir Baki (2019)The breath figure (BF) method is an effective process for fabricating porous polymeric films. In this study, we fabricated porous polymer films from thermoplastic polyurethane (PU) through static BF with CHCl3 as a solvent ... -
Potent bioactive bone cements impregnated with polystyrene-g-soybean oil-AgNPs for advanced bone tissue applications
Ilhan, Elif; Karahaliloglu, Zeynep; Kilicay, Ebru; Hazer, Baki; Denkbas, Emir Baki (2019)Postoperative infection in orthopaedic and trauma surgery is one of the most feared complications. Recently, the high prevalence of multidrug-resistant bacteria has made the antibiotic treatment ineffective; thus novel ... -
Preparation and characterization of novel albumin-sericin nanoparticles as siRNA delivery vehicle for laryngeal cancer treatment
Yalcin, Eda; Kara, Goknur; Celik, Ekin; Pinarli, Ferda Alpaslan; Saylam, Guleser; Sucularli, Ceren; Ozturk, Serhat; Yilmaz, Esin; Bayir, Omer; Korkmaz, Mehmet Hakan; Denkbas, Emir Baki (2019)Small interfering RNA (siRNA)-based gene silencing strategy has high potential on suppressing specific molecular targets, involved in cancer progression. However, the lack of an effective nanocarrier system that safely ... -
The preparation of chitosan membrane improved with nanoparticles based on unsaturated fatty acid for using in cancer-related infections
Kizaloglu, Abdullah; Kilicay, Ebru; Karahaliloglu, Zeynep; Hazer, Baki; Denkbas, Emir Baki (2020)This study includes the design of a chitosan membrane decorated with unsaturated fatty acid-based carrier system for cancer treatment and antibacterial application. For this, polystyrene-graft-polyoleic acid-graft-polyethylene ... -
Silencing of survivin and cyclin B1 through siRNA-loaded arginine modified calcium phosphate nanoparticles for non-small-cell lung cancer therapy
Kara, Goknur; Parlar, Ayhan; Cakmak, Melike Cokol; Coko, Murat; Denkbas, Emir Baki; Bakan, Feray (2020)With the development of nanotechnology, various drug delivery systems including inorganic nanoparticles, liposomes, polymers, etc. have been developed over the past decade. Some of these nanoparticles are also forthcoming ... -
Transscleral Delivery of Bevacizumab-Loaded Chitosan Nanoparticles
Ugurlu, Nagihan; Asik, Mehmet Dogan; Cakmak, Hasan Basri; Tuncer, Sema; Turk, Mustafa; Cagil, Nurullah; Denkbas, Emir Baki (2019)Purpose: The aim of this study was to synthesize bevacizumab-loaded nanoparticles and evaluate their effects on the treatment of posterior segment diseases via subtenon injections. Methods: Bevacizumab-loaded chitosan ...