Yazar "Kara, Goknur" için Mühendislik Fakültesi / Faculty of Engineering listeleme
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Designing siRNA-conjugated plant oil-based nanoparticles for gene silencing and cancer therapy
Anilmis, Nur Merve; Kara, Goknur; Kilicay, Ebru; Hazer, Baki; Denkbas, Emir Baki (2019)In this study, the anticancer activities of two siRNA carriers were compared using a human lung adenocarcinoma epithelial cell line (A549). Firstly, poly(styrene)-graft-poly(linoleic acid) (PS-g-PLina) and poly(styrene)- ... -
Development of novel poly-l-lysine-modified sericin-coated superparamagnetic iron oxide nanoparticles as siRNA carrier
Kara, Goknur; Malekghasemi, Soheil; Ozpolat, Bulent; Denkbas, Emir Baki (2021)Small interfering RNA (siRNA) is a promising therapeutic modality, however, its successful clinical application is still challenging due to the lack of safe and efficient carrier systems. Superparamagnetic iron oxide ... -
Magnetic Gelatin Nanoparticles As A Biocompatible Carrier System for Small Interfering RNA in Human Colorectal Cancer: Synthesis, Optimization, Characterization, and Cell Viability Studies
Selimovic, Amina; Kara, Goknur; Denkbas, Emir Baki (2022)Iron oxide-based nanoparticles have gained tremendous attention in developing next-generation personalized medicine modalities. Gelatin can be a good alternative for encapsulating iron oxide nanoparticles with its ... -
Magnetically responsive, sorafenib loaded alginate microspheres for hepatocellular carcinoma treatment
Alpdemir, Sukran; Vural, Tayfun; Kara, Goknur; Bayram, Cem; Haberal, Erdem; Denkbas, Emir Baki (2020)This study aimed to develop sorafenib loaded magnetic microspheres for the treatment of hepatocellular carcinoma. To achieve this goal, superparamagnetic iron oxide nanoparticles (SPIONs) were synthesised and encapsulated ... -
MiR-329 mimic based nano-therapy inhibits growth and progression of triple negative breast cancer
Kara, Goknur; Kahraman, Nermin; Denkbas, Emir Baki; Calin, George; Ozpolat, Bulent (2020) -
Preparation and characterization of novel albumin-sericin nanoparticles as siRNA delivery vehicle for laryngeal cancer treatment
Yalcin, Eda; Kara, Goknur; Celik, Ekin; Pinarli, Ferda Alpaslan; Saylam, Guleser; Sucularli, Ceren; Ozturk, Serhat; Yilmaz, Esin; Bayir, Omer; Korkmaz, Mehmet Hakan; Denkbas, Emir Baki (2019)Small interfering RNA (siRNA)-based gene silencing strategy has high potential on suppressing specific molecular targets, involved in cancer progression. However, the lack of an effective nanocarrier system that safely ... -
Silencing of survivin and cyclin B1 through siRNA-loaded arginine modified calcium phosphate nanoparticles for non-small-cell lung cancer therapy
Kara, Goknur; Parlar, Ayhan; Cakmak, Melike Cokol; Coko, Murat; Denkbas, Emir Baki; Bakan, Feray (2020)With the development of nanotechnology, various drug delivery systems including inorganic nanoparticles, liposomes, polymers, etc. have been developed over the past decade. Some of these nanoparticles are also forthcoming ...