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East Mediterranean Region Sickle Cell Disease Mortality Trial: Retrospective Multicenter Cohort Analysis of 735 Patients
(2016)
Sickle cell disease (SCD), one of the most common genetic disorders worldwide, is characterized by hemolytic anemia and tissue damage from the rigid red blood cells. Although hydroxyurea and transfusion therapy are ...
Red Blood Cell Exchange Followed by Plasma Exchange in Patients with Intrahepatic Cholestasis due to Sickle Cell Disease
(2016)
Intrahepatic cholestasis, a rare complication of sickle cell anemia, is characterized by marked hyperbilirubinemia, acute hepatic failure, and an often fatal course. In this report, we present patients with homozygous ...
Pregnancy and Sickle Cell Disease: A Review of the Current Literature
(2016)
Sickle cell disease (SCD) is the most common hereditary disease worldwide, presenting with anemia and intermittent severe pain. Pregnancy in a patient with SCD is associated with high levels of maternal and fetal morbidity ...
Red blood cell alloimmunization in patients with sickle cell disease in Turkey: a single center retrospective cohort study
(2016)
Purpose: We aimed to investigate erythrocyte alloimmunization frequency and related factors in our region where SCD is common
Material and Methods: This study was planned as a single center, cross-sectional and retrospective ...
Hematopoietic Stem Cell Transplantation in Adult Sickle Cell Disease: Problems and Solutions
(2015)
Sickle cell disease-related organ injuries cannot be prevented despite hydroxyurea use, infection prophylaxis, and supportive therapies. As a consequence, disease-related mortality reaches 14% in adolescents and young ...
Significance of electronic health records: A comparative study of vaccination rates in patients with sickle cell disease
(2017)
Objective: In this study, we investigated the influence of electronic health records (EHR) and electronic vaccination schedule applications on the vaccination status of patients who were admitted to our Center for the ...
Organ damage mitigation with the Baskent Sickle Cell Medical Care Development Program (BASCARE)
(2018)
The Eastern Mediterranean is among the regions where sickle cell disease (SCD) is common. The morbidity and mortality of this disease can be postponed to adulthood through therapies implemented in childhood. The present ...
Short-term Central Venous Catheter Complications in Patients with Sickle Cell Disease Who Undergo Apheresis
(2014)
Patients with sickle cell disease (SCD) are prone to develop thrombosis and infection due to their inflammatory and immune deficiency state. These patients require red cell exchange therapy for treatment or prevention of ...
Comparison of the clinical course of COVID-19 infection in sickle cell disease patients with healthcare professionals
(2021)
It is highly expected that COVID-19 infection will have devastating consequences in sickle cell disease (SCD) patients due to endothelial activation and decreased tissue and organ reserve as a result of microvascular ...