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dc.contributor.authorAyhan, Ali
dc.contributor.authorOzkan, Nazli Topfedaisi
dc.contributor.authorOz, Murat
dc.contributor.authorComert, Gunsu Kimyon
dc.contributor.authorCuylan, Zeliha Fırat
dc.contributor.authorCoban, Gonca
dc.contributor.authorTurkmen, Osman
dc.contributor.authorErdem, Baki
dc.contributor.authorSahin, Hanifi
dc.contributor.authorAkbayir, Ozgur
dc.contributor.authorDede, Murat
dc.contributor.authorTuran, Ahmet Taner
dc.contributor.authorCelik, Husnu
dc.contributor.authorGungor, Tayfun
dc.contributor.authorHaberal, Ali
dc.contributor.authorArvas, Macit
dc.contributor.authorMeydanli, Mehmet Mutlu
dc.date.accessioned2019-05-02T20:14:16Z
dc.date.available2019-05-02T20:14:16Z
dc.date.issued2018
dc.identifier.issn2005-0380
dc.identifier.urihttps://synapse.koreamed.org/Synapse/Data/PDFData/1114JGO/jgo-29-e48.pdf
dc.identifier.urihttp://hdl.handle.net/11727/3117
dc.description.abstractObjective: The purpose of this study was to investigate the prognostic value of lymph node ratio (LNR) in women with stage IIIC endometrioid endometrial cancer (EC). Methods: A multicenter, retrospective department database review was performed to identify patients with stage IIIC pure endometrioid EC at 6 gynecologic oncology centers in Turkey. A total of 207 women were included. LNR, defined as the percentage of positive lymph nodes (LNs) to total nodes recovered, was stratified into 2 groups: LNR1 (<= 0.15), and LNR2 (> 0.15). Kaplan-Meier method was used to generate survival data. Factors predictive of outcome were analyzed using Cox proportional hazards models. Results: One hundred and one (48.8%) were classified as stage IIIC1 and 106 (51.2%) as stage IIIC2. The median age at diagnosis was 58 (range, 30-82) and the median duration of follow-up was 40 months (range, 1-228 months). There were 167 (80.7%) women with LNR <= 0.15, and 40 (19.3%) women with LNR > 0.15. The 5-year progression-free survival (PFS) rates for LNR <= 0.15 and LNR > 0.15 were 76.1%, and 58.5%, respectively (p= 0.045). An increased LNR was associated with a decrease in 5-year overall survival (OS) from 87.0% for LNR <= 0.15 to 62.3% for LNR > 0.15 (p= 0.005). LNR > 0.15 was found to be an independent prognostic factor for both PFS (hazard ratio [HR]= 2.05; 95% confidence interval [CI]= 1.07-3.93; p= 0.03) and OS (HR= 3.35; 95% CI= 1.57-7.19; p= 0.002). Conclusion: LNR seems to be an independent prognostic factor for decreased PFS and OS in stage IIIC pure endometrioid EC.en_US
dc.language.isoengen_US
dc.relation.isversionof10.3802/jgo.2018.29.e48en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSurvival Rateen_US
dc.subjectEndometrioid Carcinomaen_US
dc.subjectEndometrial Neoplasmsen_US
dc.subjectLymph Node Excisionen_US
dc.subjectDisease-Free Survivalen_US
dc.titleImpact of lymph node ratio on survival in stage IIIC endometrioid endometrial cancer: a Turkish Gynecologic Oncology Group studyen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF GYNECOLOGIC ONCOLOGYen_US
dc.identifier.volume29en_US
dc.identifier.issue4en_US
dc.identifier.wos000433285800013


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