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dc.contributor.authorYildirir, Aylin
dc.contributor.authorYildirim, Ozge Turgay
dc.contributor.authorSade, Leyla Elif
dc.contributor.authorHasirci, Senem Has
dc.contributor.authorKozan, Hatice
dc.contributor.authorOzcalik, Emre
dc.contributor.authorOkyay, Kaan
dc.contributor.authorBal, Ugur Abbas
dc.contributor.authorAydinalp, Alp
dc.contributor.authorMuderrisoglu, Haldun
dc.date.accessioned2019-05-03T07:56:59Z
dc.date.available2019-05-03T07:56:59Z
dc.date.issued2018
dc.identifier.issn2149-2263
dc.identifier.urihttp://www.anatoljcardiol.com/jvi.aspx?pdir=anatoljcardiol&plng=eng&un=AJC-66181
dc.identifier.urihttp://hdl.handle.net/11727/3120
dc.description.abstractObjective: Resistin, a cysteine-rich peptide, is associated with atherosclerosis and diabetes. Resistin levels increase corresponding to coronary artery disease (CAD) and heart failure severity. Since resistin level tends to elevate with symptomatic heart failure, it is expected to be associated with left ventricular end-diastolic pressure (LVEDP). However, there is no relevant literature on the relationship between resistin levels and LVEDP. We aimed to evaluate the association between resistin levels and LVEDP, severity of CAD, carotid intima-media thickness (CIMT), and echocardiographic diastolic dysfunction parameters. Methods: For this study, 128 euvolemic patients with creatinine clearance >50 mg/dL and without acute coronary syndrome, who had typical chest pain or were stress test positive, were enrolled. Resistin level was measured by Enzyme-linked immunosorbent assays (ELISA) method. Severe CAD is defined as >= 50% stenosis in one of the major coronary arteries. LVEDP was measured during left heart catheterization. Results: After coronary angiography, 60 patients (46.9%) had severe CAD. The mean LVEDPs were similar for patients with and without severe CAD (p=0.480). The resistin levels did not differ between the groups (p=0.154). The resistin levels did not correlate with LVEDP (r=-0.045, p=0.627), ejection fraction (EF; r=0.110, p=0.228), the Gensini score (r=-0.091, p=0.328), and CIMT (r=0.082, p=0.457). No significant correlation was found between the echocardiographic diastolic dysfunction parameters and resistin levels. Conclusion: There was no significant correlation between resistin level and LVEDP, CAD severity, echocardiographic diastolic dysfunction parameters, and CIMT. Further studies are warranted to determine the efficacy of resistin in clinical use.en_US
dc.language.isoengen_US
dc.relation.isversionof10.14744/AnatolJCardiol.2018.66181en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectResistinen_US
dc.subjectLeft ventricular end-diastolic pressureen_US
dc.subjectCoronary artery diseaseen_US
dc.subjectCarotid intima-media thicknessen_US
dc.subjectDiastolic dysfunctionen_US
dc.titleIs there a relationship between resistin levels and left ventricular end-diastolic pressure?en_US
dc.typearticleen_US
dc.relation.journalANATOLIAN JOURNAL OF CARDIOLOGYen_US
dc.identifier.volume19en_US
dc.identifier.issue4en_US
dc.identifier.startpage267en_US
dc.identifier.endpage272en_US
dc.identifier.wos000429628000008en_US
dc.identifier.scopus2-s2.0-85045009109en_US
dc.contributor.pubmedID29615544en_US
dc.contributor.orcID0000-0002-9635-6313en_US
dc.contributor.orcID0000-0002-6731-4958en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.contributor.researcherIDAAK-7355-2020en_US
dc.contributor.researcherIDAAG-8233-2020en_US


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