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dc.contributor.authorHaberal, Mehmet
dc.contributor.authorHaberal, Nihan
dc.contributor.authorBaris, Zeren
dc.contributor.authorOzcay, Figen
dc.contributor.authorOzbek, Ozlem Yilmaz
dc.contributor.authorSarialioglu, Faik
dc.date.accessioned2019-05-06T08:21:16Z
dc.date.available2019-05-06T08:21:16Z
dc.date.issued2018
dc.identifier.issn1300-4948
dc.identifier.urihttp://www.turkjgastroenterol.org/sayilar/307/buyuk/354-60.pdf
dc.identifier.urihttp://hdl.handle.net/11727/3185
dc.description.abstractBackground/Aims: We evaluated our 16-year single-center experience of pediatric post-transplant lymphoproliferative disorder (PTLD) cases who underwent liver transplantation between 2001 and 2017. Materials and Methods: Of the 236 pediatric patients who underwent liver transplantation between 2001 and 2017, the clinical and laboratory data of eight patients diagnosed with PTLD were reviewed. The pre-transplant Epstein-Barr virus (EBV) status of 172 patients was also recorded. Results: The total incidence of PTLD was 3.4%. The incidence of PTLD was 10% in pre-transplant EBV immunoglobulin G (IgG)-seronegative patients and 0.8% in pre-transplant EBV IgG-seropositive patients. The mean age of the patients at liver transplantation was 2.71 +/- 3.21 years, and four patients were aged below 1 year at the time of transplantation. PTLD was diagnosed at 21.81 +/- 18.1 months after transplantation. The primary site of involvement was variable among patients: peripheral and mediastinal lymph nodes, stomach and intestine, transplanted graft, bone marrow, and nasopharynx. The eosinophil count varied greatly among patients, with a mean value of 524.62 +/- 679/mm3. Three patients had a food allergy and were administered an elimination diet at the time of PTLD diagnosis. Six patients had PTLD of B-cell origin. One patient died due to neutropenic sepsis during chemotherapy, whereas seven patients were followed up in full remission for 7.75 +/- 4 years. Conclusion: PTLD is a life-threatening complication of solid-organ transplantation with a heterogeneous clinical spectrum. Food allergy had a close association with PTLD. A close follow-up of patients with risk factors and an early diagnosis with appropriate treatment may lead to a better outcome.en_US
dc.language.isoengen_US
dc.relation.isversionof10.5152/tjg.2018.17731en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPost-transplant lymphoproliferative diseaseen_US
dc.subjectLiver transplantationen_US
dc.subjectEBVen_US
dc.subjectFood allergyen_US
dc.titleA single-center experience of post-transplant lymphoproliferative disorder (PTLD) cases after pediatric liver transplantation: Incidence, outcomes, and association with food allergyen_US
dc.typearticleen_US
dc.relation.journalTURKISH JOURNAL OF GASTROENTEROLOGYen_US
dc.identifier.volume29en_US
dc.identifier.issue3en_US
dc.identifier.startpage354en_US
dc.identifier.endpage360en_US
dc.identifier.wos000440300700013


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