Show simple item record

dc.contributor.authorHaberal, Ali
dc.contributor.authorCelik, Husnu
dc.contributor.authorCoban, Gonca
dc.contributor.authorOzkan, Nazli Topfedaisi
dc.contributor.authorMeydanli, Mehmet Mutlu
dc.contributor.authorSari, Mustafa Erkan
dc.contributor.authorDemirkiran, Fuat
dc.contributor.authorKahramanoglu, Ilker
dc.contributor.authorBese, Tugan
dc.contributor.authorArvas, Macit
dc.contributor.authorSahim, Hanifi
dc.contributor.authorOzge, Tufan
dc.contributor.authorYalcin, Omer Tarik
dc.contributor.authorAkbayir, Ozgur
dc.contributor.authorErdem, Baki
dc.contributor.authorNumanoglu, Ceyhun
dc.contributor.authorOzgul, Nejat
dc.contributor.authorBoyraz, Gokhan
dc.contributor.authorSalman, Mehmet Coskun
dc.contributor.authorYuce, Kunter
dc.contributor.authorDede, Murat
dc.contributor.authorYenen, Mufit Cemal
dc.contributor.authorTaskin, Salih
dc.contributor.authorAltin, Duygu
dc.contributor.authorOrtac, Ugur Firat
dc.contributor.authorAyik, Hulya Aydin
dc.contributor.authorSimsek, Tayup
dc.contributor.authorGungor, Tayfun
dc.contributor.authorGungorduk, Kemal
dc.contributor.authorSanci, Muzaffer
dc.contributor.authorAyhan, Ali
dc.date.accessioned2019-05-30T13:04:08Z
dc.date.available2019-05-30T13:04:08Z
dc.date.issued2017
dc.identifier.issn2005-0380
dc.identifier.urihttps://synapse.koreamed.org/Synapse/Data/PDFData/1114JGO/jgo-28-e65.pdf
dc.identifier.urihttp://hdl.handle.net/11727/3360
dc.description.abstractObjective: To determine factors influencing overall survival following recurrence (OSFR) in women with low-risk endometrial cancer (EC) treated with surgery alone. Methods: A multicenter, retrospective department database review was performed to identify patients with recurrent "low-risk EC" (patients having less than 50% myometrial invasion [MMI] with grade 1 or 2 endometrioid EC) at 10 gynecologic oncology centers in Turkey. Demographic, clinicopathological, and survival data were collected. Results: We identified 67 patients who developed recurrence of their EC after initially being diagnosed and treated for low-risk EC. For the entire study cohort, the median time to recurrence (TTR) was 23 months (95% confidence interval [CI]=11.5-34.5; standard error [SE]=5.8) and the median OSFR was 59 months (95% CI=12.7-105.2; SE=23.5). We observed 32 (47.8%) isolated vaginal recurrences, 6 (9%) nodal failures, 19 (28.4%) peritoneal failures, and 10 (14.9%) hematogenous disseminations. Overall, 45 relapses (67.2%) were loco-regional whereas 22 (32.8%) were extrapelvic. According to the Gynecologic Oncology Group (GOG) Trial-99, 7 (10.4%) out of 67 women with recurrent low-risk EC were qualified as high-intermediate risk (HIR). The 5-year OSFR rate was significantly higher for patients with TTR >= 36 months compared to those with TTR <36 months (74.3% compared to 33%, p=0.001). On multivariate analysis for OSFR, TTR <36 months (hazard ratio [HR]=8.46; 95% CI=1.65-43.36; p=0.010) and presence of HIR criteria (HR=4.62; 95% CI=1.69-12.58; p=0.003) were significant predictors. Conclusion: Low-risk EC patients recurring earlier than 36 months and those carrying HIR criteria seem more likely to succumb to their tumors after recurrence.en_US
dc.language.isoengen_US
dc.relation.isversionof10.3802/jgo.2017.28.e65en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndometrial Neoplasmsen_US
dc.subjectRecurrenceen_US
dc.subjectLocal Neoplasm Recurrenceen_US
dc.subjectSurvival Analysisen_US
dc.titleFactors associated with survival after relapse in patients with low-risk endometrial cancer treated with surgery aloneen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF GYNECOLOGIC ONCOLOGYen_US
dc.identifier.volume28en_US
dc.identifier.issue5en_US
dc.identifier.wos000416670000011


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record