dc.contributor.author | Haberal, Ali | |
dc.contributor.author | Celik, Husnu | |
dc.contributor.author | Coban, Gonca | |
dc.contributor.author | Ozkan, Nazli Topfedaisi | |
dc.contributor.author | Meydanli, Mehmet Mutlu | |
dc.contributor.author | Sari, Mustafa Erkan | |
dc.contributor.author | Demirkiran, Fuat | |
dc.contributor.author | Kahramanoglu, Ilker | |
dc.contributor.author | Bese, Tugan | |
dc.contributor.author | Arvas, Macit | |
dc.contributor.author | Sahim, Hanifi | |
dc.contributor.author | Ozge, Tufan | |
dc.contributor.author | Yalcin, Omer Tarik | |
dc.contributor.author | Akbayir, Ozgur | |
dc.contributor.author | Erdem, Baki | |
dc.contributor.author | Numanoglu, Ceyhun | |
dc.contributor.author | Ozgul, Nejat | |
dc.contributor.author | Boyraz, Gokhan | |
dc.contributor.author | Salman, Mehmet Coskun | |
dc.contributor.author | Yuce, Kunter | |
dc.contributor.author | Dede, Murat | |
dc.contributor.author | Yenen, Mufit Cemal | |
dc.contributor.author | Taskin, Salih | |
dc.contributor.author | Altin, Duygu | |
dc.contributor.author | Ortac, Ugur Firat | |
dc.contributor.author | Ayik, Hulya Aydin | |
dc.contributor.author | Simsek, Tayup | |
dc.contributor.author | Gungor, Tayfun | |
dc.contributor.author | Gungorduk, Kemal | |
dc.contributor.author | Sanci, Muzaffer | |
dc.contributor.author | Ayhan, Ali | |
dc.date.accessioned | 2019-05-30T13:04:08Z | |
dc.date.available | 2019-05-30T13:04:08Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 2005-0380 | |
dc.identifier.uri | https://synapse.koreamed.org/Synapse/Data/PDFData/1114JGO/jgo-28-e65.pdf | |
dc.identifier.uri | http://hdl.handle.net/11727/3360 | |
dc.description.abstract | Objective: To determine factors influencing overall survival following recurrence (OSFR) in women with low-risk endometrial cancer (EC) treated with surgery alone.
Methods: A multicenter, retrospective department database review was performed to identify patients with recurrent "low-risk EC" (patients having less than 50% myometrial invasion [MMI] with grade 1 or 2 endometrioid EC) at 10 gynecologic oncology centers in Turkey. Demographic, clinicopathological, and survival data were collected.
Results: We identified 67 patients who developed recurrence of their EC after initially being diagnosed and treated for low-risk EC. For the entire study cohort, the median time to recurrence (TTR) was 23 months (95% confidence interval [CI]=11.5-34.5; standard error [SE]=5.8) and the median OSFR was 59 months (95% CI=12.7-105.2; SE=23.5). We observed 32 (47.8%) isolated vaginal recurrences, 6 (9%) nodal failures, 19 (28.4%) peritoneal failures, and 10 (14.9%) hematogenous disseminations. Overall, 45 relapses (67.2%) were loco-regional whereas 22 (32.8%) were extrapelvic. According to the Gynecologic Oncology Group (GOG) Trial-99, 7 (10.4%) out of 67 women with recurrent low-risk EC were qualified as high-intermediate risk (HIR). The 5-year OSFR rate was significantly higher for patients with TTR >= 36 months compared to those with TTR <36 months (74.3% compared to 33%, p=0.001). On multivariate analysis for OSFR, TTR <36 months (hazard ratio [HR]=8.46; 95% CI=1.65-43.36; p=0.010) and presence of HIR criteria (HR=4.62; 95% CI=1.69-12.58; p=0.003) were significant predictors.
Conclusion: Low-risk EC patients recurring earlier than 36 months and those carrying HIR criteria seem more likely to succumb to their tumors after recurrence. | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | 10.3802/jgo.2017.28.e65 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Endometrial Neoplasms | en_US |
dc.subject | Recurrence | en_US |
dc.subject | Local Neoplasm Recurrence | en_US |
dc.subject | Survival Analysis | en_US |
dc.title | Factors associated with survival after relapse in patients with low-risk endometrial cancer treated with surgery alone | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF GYNECOLOGIC ONCOLOGY | en_US |
dc.identifier.volume | 28 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.wos | 000416670000011 | en_US |
dc.identifier.scopus | 2-s2.0-85026749997 | en_US |
dc.contributor.pubmedID | 28657226 | en_US |
dc.contributor.orcID | 0000-0002-1486-7209 | en_US |
dc.contributor.orcID | 0000-0002-3285-5519 | en_US |
dc.contributor.orcID | 0000-0003-1185-9227 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | en_US |
dc.contributor.researcherID | AAI-9331-2021 | en_US |
dc.contributor.researcherID | AAJ-5802-2021 | en_US |
dc.contributor.researcherID | AAL-1923-2021 | en_US |
dc.contributor.researcherID | AAI-9974-2021 | en_US |