dc.contributor.author | Dirim, Ayhan | |
dc.contributor.author | Ozkan, Tayyar Alp | |
dc.contributor.author | Eskicorapci, Sadettin | |
dc.contributor.author | Yaycioglu, Ozgur | |
dc.contributor.author | Akdogan, Bulent | |
dc.contributor.author | Gogus, Cagatay | |
dc.contributor.author | Can, Cavit | |
dc.contributor.author | Yildirim, Asif | |
dc.contributor.author | Ozen, Haluk | |
dc.contributor.author | Tukeri, Levent | |
dc.date.accessioned | 2019-06-10T19:15:55Z | |
dc.date.available | 2019-06-10T19:15:55Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 2148-9580 | |
dc.identifier.uri | http://cms.galenos.com.tr/Uploads/Article_15912/53-60.pdf | |
dc.identifier.uri | http://hdl.handle.net/11727/3429 | |
dc.description.abstract | Objective: The American Joint Committee on Cancer tumor-node-metastasis (TNM) classification has been updated by the 7th edition in 2010. The objective of the study was to evaluate cancer-specific survival (CSS) in patients with renal cell carcinoma (RCC) and assess the concordance of 2002 and novel 2010 TNM primary tumor classifications.
Materials and Methods: A retrospective analysis of RCC registries from 25 institutions of the Urooncology Association of Turkey Renal CancerStudy Group was performed. Patients with RCC had a radical or partial nephrectomy. The database consisted of 1889 patients.
Results: Median follow-up time was 25 months (interquartile range: 11.2-47.8). The 5-year CSS rate for pT1a, pT1b, pT2a, pT2b, pT3a and pT4 tumors were 97% [95% confidence interval (CI): 0.93-0.99], 94% (95% CI: 0.91-0.97), 88% (95% CI: 0.81-0.93), 77% (95% CI: 0.64-0.86) 74% (95% CI: 0.65-0.81) and 66% (95% CI: 0.51-0.77), respectively according to the 2010 TNM classification (p<0.001). CSS comparisons between pT1a-pT1b (p=0.022), pT1b-pT2a (p=0.030), pT3a-pT3b (p<0.001) and pT3b-pT4 (p=0.020) were statistically significant. Conversely, pT2a-pT2b (p=0.070) and pT2b-pT3a (p=0.314) were not statistically significant. Multivariable analyses revealed the pT stage in the 2010 TNM classification as an independent prognostic factor for CSS (p for trend=0.002). C-indexes for 2002 and 2010 TNM classifications were 0.8683 and 0.8706, respectively.
Conclusion: Subdividing pT2 does not have a CSS advantage. Moving adrenal involvement to pT4 yielded a more accurate prognosis prediction. T stage and LNI are independent prognostic factors for CSS in RCC. Overall, the novel 2010 TNM classification is slightly improved over the former one. However, shown by C-index values, this improvement is not sufficient to state that 2010 TNM outperforms the 2002 TNM. | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | 10.4274/jus.1369 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Renal cell carcinoma | en_US |
dc.subject | Kidney cancer | en_US |
dc.subject | 2010 tumor-node-metastasis | en_US |
dc.subject | Primary tumor classification | en_US |
dc.title | An Independent Validation of 2010 Tumor-Node-Metastasis Classification for Renal Cell Carcinoma: A Multi-center Study by the Urooncology Association of Turkey Renal Cancer-Study Group | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF UROLOGICAL SURGERY | en_US |
dc.identifier.volume | 4 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 53 | en_US |
dc.identifier.endpage | 60 | en_US |
dc.identifier.wos | 000411191800002 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | en_US |