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dc.contributor.authorDirim, Ayhan
dc.contributor.authorOzkan, Tayyar Alp
dc.contributor.authorEskicorapci, Sadettin
dc.contributor.authorYaycioglu, Ozgur
dc.contributor.authorAkdogan, Bulent
dc.contributor.authorGogus, Cagatay
dc.contributor.authorCan, Cavit
dc.contributor.authorYildirim, Asif
dc.contributor.authorOzen, Haluk
dc.contributor.authorTukeri, Levent
dc.date.accessioned2019-06-10T19:15:55Z
dc.date.available2019-06-10T19:15:55Z
dc.date.issued2017
dc.identifier.issn2148-9580
dc.identifier.urihttp://cms.galenos.com.tr/Uploads/Article_15912/53-60.pdf
dc.identifier.urihttp://hdl.handle.net/11727/3429
dc.description.abstractObjective: The American Joint Committee on Cancer tumor-node-metastasis (TNM) classification has been updated by the 7th edition in 2010. The objective of the study was to evaluate cancer-specific survival (CSS) in patients with renal cell carcinoma (RCC) and assess the concordance of 2002 and novel 2010 TNM primary tumor classifications. Materials and Methods: A retrospective analysis of RCC registries from 25 institutions of the Urooncology Association of Turkey Renal CancerStudy Group was performed. Patients with RCC had a radical or partial nephrectomy. The database consisted of 1889 patients. Results: Median follow-up time was 25 months (interquartile range: 11.2-47.8). The 5-year CSS rate for pT1a, pT1b, pT2a, pT2b, pT3a and pT4 tumors were 97% [95% confidence interval (CI): 0.93-0.99], 94% (95% CI: 0.91-0.97), 88% (95% CI: 0.81-0.93), 77% (95% CI: 0.64-0.86) 74% (95% CI: 0.65-0.81) and 66% (95% CI: 0.51-0.77), respectively according to the 2010 TNM classification (p<0.001). CSS comparisons between pT1a-pT1b (p=0.022), pT1b-pT2a (p=0.030), pT3a-pT3b (p<0.001) and pT3b-pT4 (p=0.020) were statistically significant. Conversely, pT2a-pT2b (p=0.070) and pT2b-pT3a (p=0.314) were not statistically significant. Multivariable analyses revealed the pT stage in the 2010 TNM classification as an independent prognostic factor for CSS (p for trend=0.002). C-indexes for 2002 and 2010 TNM classifications were 0.8683 and 0.8706, respectively. Conclusion: Subdividing pT2 does not have a CSS advantage. Moving adrenal involvement to pT4 yielded a more accurate prognosis prediction. T stage and LNI are independent prognostic factors for CSS in RCC. Overall, the novel 2010 TNM classification is slightly improved over the former one. However, shown by C-index values, this improvement is not sufficient to state that 2010 TNM outperforms the 2002 TNM.en_US
dc.language.isoengen_US
dc.relation.isversionof10.4274/jus.1369en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRenal cell carcinomaen_US
dc.subjectKidney canceren_US
dc.subject2010 tumor-node-metastasisen_US
dc.subjectPrimary tumor classificationen_US
dc.titleAn Independent Validation of 2010 Tumor-Node-Metastasis Classification for Renal Cell Carcinoma: A Multi-center Study by the Urooncology Association of Turkey Renal Cancer-Study Groupen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF UROLOGICAL SURGERYen_US
dc.identifier.volume4en_US
dc.identifier.issue2en_US
dc.identifier.startpage53en_US
dc.identifier.endpage60en_US
dc.identifier.wos000411191800002en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US


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