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dc.contributor.authorSari, Mustafa Erkan
dc.contributor.authorMeydanli, Mehmet Mutlu
dc.contributor.authorTurkmen, Osman
dc.contributor.authorComert, Gunsu Kimyon
dc.contributor.authorTuran, Ahmet Taner
dc.contributor.authorKaralok, Alper
dc.contributor.authorSahin, Hanifi
dc.contributor.authorKocaman, Eda
dc.contributor.authorAkbayir, Ozgur
dc.date.accessioned2019-06-12T20:07:13Z
dc.date.available2019-06-12T20:07:13Z
dc.date.issued2017
dc.identifier.issn2005-0380
dc.identifier.urihttps://synapse.koreamed.org/Synapse/Data/PDFData/1114JGO/jgo-28-e49.pdf
dc.identifier.urihttp://hdl.handle.net/11727/3480
dc.description.abstractObjective: To assess the prognosis of surgically-staged non-invasive uterine clear cell carcinoma (UCCC), and to determine the role of adjuvant therapy. Methods: A multicenter, retrospective department database review was performed to identify patients with UCCC who underwent surgical treatment between 1997 and 2016 at 8 Gynecologic Oncology Centers. Demographic, clinicopathological, and survival data were collected. Results: A total of 232 women with UCCC were identified. Of these, 53 (22.8%) had surgically-staged non-invasive UCCC. Twelve patients (22.6%) were upstaged at surgical assessment, including a 5.6% rate of lymphatic dissemination (3/53). Of those, 1 had stage IIIA, 1 had stage IIIC1, 1 had stage IIIC2, and 9 had stage IVB disease. Of the 9 women with stage IVB disease, 5 had isolated omental involvement indicating omentum as the most common metastatic site. UCCC limited only to the endometrium with no extra-uterine disease was confirmed in 41 women (73.3%) after surgical staging. Of those, 13 women (32%) were observed without adjuvant treatment whereas 28 patients (68%) underwent adjuvant therapy. The 5-year disease-free survival rates for patients with and without adjuvant treatment were 100.0% vs. 74.1%, respectively (p=0.060). Conclusion: Extra-uterine disease may occur in the absence of myometrial invasion (MMI), therefore comprehensive surgical staging including omentectomy should be the standard of care for women with UCCC regardless of the depth of MMI. Larger cohorts are needed in order to clarify the necessity of adjuvant treatment for women with UCCC truly confined to the endometrium.en_US
dc.language.isoengen_US
dc.relation.isversionof10.3802/jgo.2017.28.e49en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRadiotherapyen_US
dc.subjectAdjuvanten_US
dc.subjectChemotherapyen_US
dc.subjectAdjuvanten_US
dc.subjectEndometriumen_US
dc.subjectNeoplasm Invasivenessen_US
dc.subjectAdenocarcinomaen_US
dc.subjectClear Cellen_US
dc.subjectUterine Diseasesen_US
dc.titlePrognostic factors and treatment outcomes in surgically-staged non-invasive uterine clear cell carcinoma: a Turkish Gynecologic Oncology Group studyen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF GYNECOLOGIC ONCOLOGYen_US
dc.identifier.volume28en_US
dc.identifier.issue4en_US
dc.identifier.wos000403955700012


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