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dc.contributor.authorHaberal, Mehmet
dc.contributor.authorErsoy, Zeynep
dc.contributor.authorKaplan, Serife
dc.contributor.authorOzdemirkan, Aycan
dc.contributor.authorTorgay, Adnan
dc.contributor.authorArslan, Gulnaz
dc.contributor.authorPirat, Arash
dc.date.accessioned2019-06-13T13:25:17Z
dc.date.available2019-06-13T13:25:17Z
dc.date.issued2017
dc.identifier.issn1304-0855
dc.identifier.urihttp://ectrx.org/forms/ectrxcontentshow.php?doi_id=10.6002/ect.mesot2016.O32&year=2017&volume=15&issue=1&supplement=1&makale_no=0&spage_number=53&content_type=PDF
dc.identifier.urihttp://hdl.handle.net/11727/3510
dc.description.abstractObjectives: To analyze how graft-weight-to-body-weight ratio in pediatric liver transplant affects intraoperative and early postoperative hemodynamic and metabolic parameters. Materials and Methods: We reviewed data from 130 children who underwent liver transplant between 2005 and 2015. Recipients were divided into 2 groups: those with a graft weight to body weight ratio > 4% (large for size) and those with a ratio <= 4% (normal for size). Data included demographics, preoperative laboratory findings, intraoperative metabolic and hemodynamic parameters, and intensive care follow-up parameters. Results: Patients in the large-graft-for-size group (>4%) received more colloid solution (57.7 +/- 20.1 mL/kg vs 45.1 +/- 21.9 mL/kg; P = .08) and higher doses of furosemide (0.7 +/- 0.6 mg/kg vs 0.4 +/- 0.7 mg/kg; P = .018). They had lower mean pH (7.1 +/- 0.1 vs 7.2 +/- 0.1; P = .004) and PO2 (115.4 +/- 44.6 mm Hg vs 147.6 +/- 49.3 mm Hg; P = .004) values, higher blood glucose values (352.8 +/- 96.9 mg/dL vs 262.8 +/- 88.2 mg/dL; P < .001), and lower mean body temperature (34.8 +/- 0.7 degrees C vs 35.2 +/- 0.6 degrees C; P = .016) during the neohepatic phase. They received more blood transfusions during both the anhepatic (30.3 +/- 24.3 mL/kg vs 18.8 +/- 21.8 mL/kg; P = .013) and neohepatic (17.7 +/- 20.4 mL/kg vs 10.3 +/- 15.5 mL/kg; P = .031) phases and more fresh frozen plasma (13.6 +/- 17.6 mL/kg vs 6.2 +/- 10.2 mL/kg; P = .012) during the neohepatic phase. They also were more likely to be hypotensive (P < .05) and to receive norepinephrine infusion more often (44% vs 22%; P < .05) intra-operatively. More patients in this group were mechanically ventilated in the intensive care unit (56% vs 31%; P = .035). There were no significant differences between the groups in postoperative acute renal dysfunction, graft rejection or loss, infections, length of intensive care stay, and mortality (P > .05). Conclusions: High graft weight-to-body-weight ratio is associated with adverse metabolic and hemodynamic changes during the intraoperative and early postoperative periods. These results emphasize the importance of using an appropriately sized graft in liver transplant.en_US
dc.language.isoengen_US
dc.relation.isversionof10.6002/ect.mesot2016.O32en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHemodynamic changesen_US
dc.subjectLarge graft for sizeen_US
dc.subjectMetabolic changesen_US
dc.subjectNormal graft for sizeen_US
dc.subjectPediatric patientsen_US
dc.titleEffect of Graft Weight to Recipient Body Weight Ratio on Hemodynamic and Metabolic Parameters in Pediatric Liver Transplant: A Retrospective Analysisen_US
dc.typearticleen_US
dc.relation.journalEXPERIMENTAL AND CLINICAL TRANSPLANTATIONen_US
dc.identifier.volume15en_US
dc.identifier.startpage53en_US
dc.identifier.endpage56en_US
dc.identifier.wos000399333200013


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