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dc.contributor.authorİyidir, Ozlem Turhan
dc.contributor.authorDemir, Ozgur
dc.contributor.authorEmral, Rifat
dc.date.accessioned2019-06-14T07:28:26Z
dc.date.available2019-06-14T07:28:26Z
dc.date.issued2017
dc.identifier.issn2147-2092
dc.identifier.urihttp://medicaljournal.gazi.edu.tr/index.php/GMJ/article/view/1326
dc.identifier.urihttp://hdl.handle.net/11727/3540
dc.description.abstractObjective: There is an increasing evidence that glucagon and growth hormone (GH)-insulin-like growth factor (IGF) axis may play an important role in glucose metabolism since early stages of glucose intolerance. Carotid intima media thickness is a marker for subclinical atherosclerosis. We aimed to evaluate glucagon, GH and IGF-1 in prediabetic states and their relationship with carotid intima media thickness. Methods: One hundred subjects underwent a 75 gr oral glucose tolerance test and were divided into 4 groups according to their state of glucose tolerance: (i) normal glucose tolerance (NGT)/Controls (n=21), (ii) impaired glucose tolerance (IGT) (n=35), (iii) impaired fasting glucose (IFG) (n=22), (iv) type 2 diabetes mellitus (n=22). Insulin, glucagon and GH were measured at 0, 60 and 120. minutes of OGTT and their area under the curve (AUC) were calculated. Fasting IGF-1 levels and carotid intima media thickness were determined in all participants. Results: AUC for Glucagon was significantly higher in subjects with IGT, IFG and type 2 diabetes mellitus compared to NGT subjects. AUC for GH was significantly higher in subjects with IFG compared to subjects with IGT, type 2 diabetes mellitus and NGT. Plasma IGF-1 levels were significantly lower in subjects with abnormal glucose tolerance. CIMT was significantly higher in IFG group and CIMT was found to be negatively correlated with IGF-1 levels in subjects with IFG. Conclusion: There are pathological alterations of glucagon, GH-IGF-1 and insulin in prediabetic stages. Among these alterations insulin resistance and IGF-1 are associated with CIMT. Further studies needed to investigate the role of treatments targeting insulin sensitivity will have an impact on the association between insulin and early atherogenesisen_US
dc.language.isoengen_US
dc.relation.isversionof10.12996/gmj.2017.06en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGlucose intoleranceen_US
dc.subjectInsulin like Growth Factor-1en_US
dc.subjectCarotid intima media thicknessen_US
dc.subjectInsulin resistanceen_US
dc.titleInsulin, Glucagon and Growth Hormone and CIMT in Glucose Intoleranceen_US
dc.typearticleen_US
dc.relation.journalGAZI MEDICAL JOURNALen_US
dc.identifier.volume28en_US
dc.identifier.issue1en_US
dc.identifier.startpage22en_US
dc.identifier.endpage26en_US
dc.identifier.wos000396710600006en_US
dc.identifier.scopus2-s2.0-85007296443en_US
dc.contributor.orcID0000-0001-5305-6807en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.contributor.researcherIDK-7904-2019en_US


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