dc.contributor.author | İyidir, Ozlem Turhan | |
dc.contributor.author | Demir, Ozgur | |
dc.contributor.author | Emral, Rifat | |
dc.date.accessioned | 2019-06-14T07:28:26Z | |
dc.date.available | 2019-06-14T07:28:26Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 2147-2092 | |
dc.identifier.uri | http://medicaljournal.gazi.edu.tr/index.php/GMJ/article/view/1326 | |
dc.identifier.uri | http://hdl.handle.net/11727/3540 | |
dc.description.abstract | Objective: There is an increasing evidence that glucagon and growth hormone (GH)-insulin-like growth factor (IGF) axis may play an important role in glucose metabolism since early stages of glucose intolerance. Carotid intima media thickness is a marker for subclinical atherosclerosis. We aimed to evaluate glucagon, GH and IGF-1 in prediabetic states and their relationship with carotid intima media thickness.
Methods: One hundred subjects underwent a 75 gr oral glucose tolerance test and were divided into 4 groups according to their state of glucose tolerance: (i) normal glucose tolerance (NGT)/Controls (n=21), (ii) impaired glucose tolerance (IGT) (n=35), (iii) impaired fasting glucose (IFG) (n=22), (iv) type 2 diabetes mellitus (n=22). Insulin, glucagon and GH were measured at 0, 60 and 120. minutes of OGTT and their area under the curve (AUC) were calculated. Fasting IGF-1 levels and carotid intima media thickness were determined in all participants.
Results: AUC for Glucagon was significantly higher in subjects with IGT, IFG and type 2 diabetes mellitus compared to NGT subjects. AUC for GH was significantly higher in subjects with IFG compared to subjects with IGT, type 2 diabetes mellitus and NGT. Plasma IGF-1 levels were significantly lower in subjects with abnormal glucose tolerance. CIMT was significantly higher in IFG group and CIMT was found to be negatively correlated with IGF-1 levels in subjects with IFG.
Conclusion: There are pathological alterations of glucagon, GH-IGF-1 and insulin in prediabetic stages. Among these alterations insulin resistance and IGF-1 are associated with CIMT. Further studies needed to investigate the role of treatments targeting insulin sensitivity will have an impact on the association between insulin and early atherogenesis | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | 10.12996/gmj.2017.06 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Glucose intolerance | en_US |
dc.subject | Insulin like Growth Factor-1 | en_US |
dc.subject | Carotid intima media thickness | en_US |
dc.subject | Insulin resistance | en_US |
dc.title | Insulin, Glucagon and Growth Hormone and CIMT in Glucose Intolerance | en_US |
dc.type | article | en_US |
dc.relation.journal | GAZI MEDICAL JOURNAL | en_US |
dc.identifier.volume | 28 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 22 | en_US |
dc.identifier.endpage | 26 | en_US |
dc.identifier.wos | 000396710600006 | en_US |
dc.identifier.scopus | 2-s2.0-85007296443 | en_US |
dc.contributor.orcID | 0000-0001-5305-6807 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | en_US |
dc.contributor.researcherID | K-7904-2019 | en_US |