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dc.contributor.authorPirat, Bahar
dc.contributor.authorBaysal, Sadettin Selcuk
dc.contributor.authorOkay, Kaan
dc.contributor.authorBal, Ugur Abbas
dc.contributor.authorUlucam, Melek Zekiye
dc.contributor.authorOztuna, Derya
dc.contributor.authorMuderrisoglu, Haldun
dc.date.accessioned2019-06-14T08:23:05Z
dc.date.available2019-06-14T08:23:05Z
dc.date.issued2017
dc.identifier.issn2149-2263
dc.identifier.urihttps://www.journalagent.com/anatoljcardiol/pdfs/AJC_17_2_125_131.pdf
dc.identifier.urihttp://hdl.handle.net/11727/3546
dc.description.abstractOBJECTIVE: We examined the change in apelin concentration and its relationship with left ventricular diastolic function in patients treated for hypertension. METHODS: Ninety treatment-naive patients with newly diagnosed hypertension and 33 age- and sex-matched control subjects were prospectively enrolled. Patients with hypertension were randomized to treatment either with telmisartan 80 mg or amlodipine 10 mg. Apelin concentration was measured and echocardiography was performed at baseline and after 1 month of treatment. RESULTS: The data of 77 patients and 33 controls were analyzed. Mean age, gender, baseline blood pressure, apelin levels, and echocardiographic measurements were similar between the treatment groups (p>0.05 for all). Apelin concentration was significantly lower in patients with hypertension than in controls. There was a significant increase in apelin level after 1 month of treatment in both groups (0.32 +/- 0.17 vs. 0.38 +/- 0.17 ng/dL in telmisartan group, p=0.009, and 0.27 +/- 0.13 vs. 0.34 +/- 0.18 ng/dL in amlodipine group, p=0.013). Diastolic function improved significantly in both groups (p<0.05) but was not significantly associated with change in apelin concentration. CONCLUSION: Apelin concentration increased significantly after 1 month of effective treatment with telmisartan or amlodipine to a similar extent. Change in apelin concentration was not associated with improvement in diastolic functionen_US
dc.language.isoengen_US
dc.relation.isversionof10.14744/AnatolJCardiol.2016.7035en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApelinen_US
dc.subjectHypertensionen_US
dc.subjectDiastolic functionen_US
dc.titleTreatment-associated change in apelin concentration in patients with hypertension and its relationship with left ventricular diastolic functionen_US
dc.typearticleen_US
dc.relation.journalANATOLIAN JOURNAL OF CARDIOLOGYen_US
dc.identifier.volume17en_US
dc.identifier.issue2en_US
dc.identifier.startpage125en_US
dc.identifier.endpage131en_US
dc.identifier.wos000396901400009en_US
dc.identifier.scopus2-s2.0-85015296799en_US
dc.contributor.pubmedID27599667en_US
dc.contributor.orcID0000-0003-4576-8630en_US
dc.contributor.orcID0000-0002-9635-6313en_US
dc.contributor.orcID0000-0002-9446-2518en_US
dc.contributor.orcID0000-0002-4107-3500en_US
dc.contributor.orcID0000-0001-6134-8826en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.contributor.researcherIDAAI-8897-2021en_US
dc.contributor.researcherIDAAG-8233-2020en_US
dc.contributor.researcherIDAAK-4322-2021en_US
dc.contributor.researcherIDABD-7240-2021en_US
dc.contributor.researcherIDAAK-7355-2020en_US


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