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dc.contributor.authorOncu, Elif
dc.contributor.authorBayram, Burak
dc.contributor.authorKantarci, Alpdogan
dc.contributor.authorGulsever, Serap
dc.contributor.authorAlaaddinoglu, Emine-Elif
dc.date.accessioned2019-06-20T08:10:28Z
dc.date.available2019-06-20T08:10:28Z
dc.date.issued2016
dc.identifier.issn1698-6946
dc.identifier.urihttp://www.medicinaoral.com/medoralfree01/aop/21026.pdf
dc.identifier.urihttp://hdl.handle.net/11727/3614
dc.description.abstractBackground: Leukocyte-platelet rich fibrin (L-PRF) is a second generation platelet concentrate clinically used to accelerate tissue healing and bone regeneration. Achieving reduced implant osseointegration time could provide immediate or early loading of implants. The aim of this study was to evaluate the L-PRF-induced osseointegration and bone-implant contact (BIC) in an experimental animal model. Material and Methods: Twelve 4-month-old New Zealand white rabbits were used. Following general anesthesia, 3-5 mL of blood was obtained from the central artery in rabbit ear and L-PRF was prepared. Two implant cavities (5 mm long and 3 mm in diameter) were created in each tibia with a total of four cavities in each animal. Two of these cavities were selected and covered with PRF (test group). The remaining L-PRF was used to soak the implants placed into the L-PRF covered sockets. Other cavities were left as controls. In total, 48 implants were placed. Animals were sacrificed after two, three, or four weeks. Histological samples were obtained and peri-implant tissues were histomorphometrically evaluated for bone-to-implant contact and new bone formation. Results: Histomorphometric analyses of the defects revealed that the L-PRF was detectable up to the second week. Application of L-PRF increased the rate and amount of new bone formation in the experimental group compared to the control group. Bone-to-implant contact was enhanced when the surface was pre-wetted with L-PRF (p<0.01). Conclusions: The results of this study demonstrated that L-PRF application may increases amount and rate of new bone formation during the early healing period and provides a faster osseointegration around implants.en_US
dc.language.isoengen_US
dc.relation.isversionof10.4317/medoral.21026en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDental implantsen_US
dc.subjectPlatelet rich fibrinen_US
dc.subjectOsseointegrationen_US
dc.subjectBone Regenerationen_US
dc.subjectMatrix for growth factorsen_US
dc.titlePositive effect of platelet rich fibrin on osseointegrationen_US
dc.typearticleen_US
dc.relation.journalMEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCALen_US
dc.identifier.volume21en_US
dc.identifier.issue5en_US
dc.identifier.startpageE601en_US
dc.identifier.endpageE607en_US
dc.identifier.wos000391193600010


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