Effect of Topical Platelet-Rich Plasma on Burn Healing After Partial-Thickness Burn Injury
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Tarih
2016Yazar
Ozcelik, Umit
Ekici, Yahya
Bircan, Huseyin Yuce
Aydogan, Cem
Turkoglu, Suna
Ozen, Ozlem
Moray, Gokhan
Haberal, Mehmet
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Background: To investigate the effects of platelet-rich plasma on tissue maturation and burn healing in an experimental partial-thickness burn injury model.
Material/Methods: Thirty Wistar albino rats were divided into 3 groups of 10 rats each. Group 1 (platelet-rich plasma group) was exposed to burn injury and topical platelet-rich plasma was applied. Group 2 (control group) was exposed to burn injury only. Group 3 (blood donor group) was used as blood donors for platelet-rich plasma. The rats were killed on the seventh day after burn injury. Tissue hydroxyproline levels were measured and histopathologic changes were examined.
Results: Hydroxyproline levels were significantly higher in the platelet-rich plasma group than in the control group (P=.03). Histopathologically, there was significantly less inflammatory cell infiltration (P=.005) and there were no statistically significant differences between groups in fibroblast development, collagen production, vessel proliferations, or epithelization.
Conclusions: Platelet-rich plasma seems to partially improve burn healing in this experimental burn injury model. As an initial conclusion, it appears that platelet-rich plasma can be used in humans, although further studies should be performed with this type of treatment.
Bağlantı
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4913826&blobtype=pdfhttp://hdl.handle.net/11727/3836