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Lactobacillus rhamnosus could inhibit Porphyromonas gingivalis derived CXCL8 attenuation

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1678-7757-jaos-24-1-0067.pdf (361.6Kb)
Date
2016
Author
Mendi, Aysegul
Kose, Sevil
Uckan, Duygu
Akca, Gulcin
Yilmaz, Dervis
Aral, Levent
Gultekin, Sibel Elif
Eroglu, Tamer
Kilic, Emine
Uckan, Sina
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Abstract
An increasing body of evidence suggests that the use of probiotic bacteria is a promising intervention approach for the treatment of inflammatory diseases with a polymicrobial etiology. P. gingivalis has been noted to have a different way of interacting with the innate immune response of the host compared to other pathogenic bacteria, which is a recognized feature that inhibits CXCL8 expression. Objective The aim of the study was to determine if P. gingivalis infection modulates the inflammatory response of gingival stromal stem cells (G-MSSCs), including the release of CXCL8, and the expression of TLRs and if immunomodulatory L. rhamnosus ATCC9595 could prevent CXCL8 inhibition in experimental inflammation. Material and Methods G-MSSCs were pretreated with L. rhamnosus ATCC9595 and then stimulated with P. gingivalis ATCC33277. CXCL8 and IL-10 levels were investigated with ELISA and the TLR-4 and 2 were determined through flow cytometer analysis. Results CXCL8 was suppressed by P. gingivalis and L. rhamnosus ATCC9595, whereas incubation with both strains did not abolish CXCL8. L. rhamnosus ATCC9595 scaled down the expression of TLR4 and induced TLR2 expression when exposed to P. gingivalis stimulation (p<0.01). Conclusions These findings provide evidence that L. rhamnosus ATCC9595 can modulate the inflammatory signals and could introduce P. gingivalis to immune systems by inducing CXCL8 secretion.
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http://www.scielo.br/pdf/jaos/v24n1/1678-7757-jaos-24-1-0067.pdf
http://hdl.handle.net/11727/3908
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  • Diş Hekimliği Fakültesi / Faculty of Dentistry [118]
  • PubMed İndeksli Yayınlar Koleksiyonu [1656]
  • Scopus İndeksli Yayınlar Koleksiyonu [2051]
  • Wos İndeksli Yayınlar Koleksiyonu [2860]

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