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dc.contributor.authorAbbasoglu, Aslihan
dc.contributor.authorSarialioglu, Faik
dc.contributor.authorYazici, Nalan
dc.contributor.authorBayraktar, Nilufer
dc.contributor.authorHaberal, Aysegul
dc.contributor.authorErbay, Ayse
dc.date.accessioned2019-11-29T15:41:09Z
dc.date.available2019-11-29T15:41:09Z
dc.date.issued2015
dc.identifier.issn1875-9572
dc.identifier.urihttps://www.clinicalkey.com/service/content/pdf/watermarked/1-s2.0-S1875957214001375.pdf?locale=en_US&searchIndex=
dc.identifier.urihttp://hdl.handle.net/11727/4305
dc.description.abstractBackground: Elevated serum levels of neuron-specific enolase (NSE) was initially assumed to be specific to neuronal tumors (particularly neuroblastoma), but is now known to accompany nontumoral conditions and tumors other than neuroblastomas. There is a need to establish normal ranges for NSE, especially in early infancy. The aims of this study were to determine reference values for NSE in newborns and young infants and to assess whether NSE levels in early infancy (i.e., preterm infants and term infants) differ from the adult reference range for this enzyme. Methods: We enrolled 140 healthy babies, which included 40 preterm newborns (3-15 days old and born at 28-42 weeks gestation), 40 term newborns (< 1 month old and born at term), and 60 young infants 1-3 months old (n = 20 per subgroup of 1-, 2-, and 3-month-old infants). The determination of NSE levels was performed by the electrochemiluminescence immunoassay (ECLIA) method using the Elecysys 2010 device (Roche Diagnostics, Mannheim, Germany). The mean serum NSE levels for the preterm newborns was 21.83 +/- 15.06 ng/mL [95% confidence interval (95%Cl), 16.95-26.71 ng/mL]; term newborns, 18.06 +/- 12.83 ng/mL (95%Cl, 13.94-22.19 ng/mL); and young infants, 9.09 +/- 4.38 ng/mL (95%Cl, 7.96 -10.23 ng/mL). The mean serum NSE level for infants 1-3 months old was within the ECLIA kit's normal range (4.7-18 ng/mL for adults), whereas the corresponding means for the preterm and term newborns were higher (p < 0.001, for both). Conclusion: Our findings suggest that adult reference values should not be applied to the pre-term and term age groups. Copyright (C) 2014, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. All rights reserved.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1016/j.pedneo.2014.07.005en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectinfanten_US
dc.subjectneuron-specific enolaseen_US
dc.subjectreference valuesen_US
dc.titleSerum Neuron-specific Enolase Levels in Preterm and Term Newborns and in Infants 1-3 Months of Ageen_US
dc.typearticleen_US
dc.relation.journalPEDIATRICS AND NEONATOLOGYen_US
dc.identifier.volume58en_US
dc.identifier.issue2en_US
dc.identifier.startpage114en_US
dc.identifier.endpage119en_US
dc.identifier.wos000354148500009


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