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dc.contributor.authorVerdi, Hasibe
dc.contributor.authorKinik, Sibel Tulgar
dc.contributor.authorYalcin, Yaprak Yilmaz
dc.contributor.authorSahin, Nursel Muratoglu
dc.contributor.authorYazici, Ayse Canan
dc.contributor.authorAtac, F.Belgin
dc.date.accessioned2019-12-06T07:54:15Z
dc.date.available2019-12-06T07:54:15Z
dc.date.issued2015
dc.identifier.issn1308-5727
dc.identifier.urihttp://cms.galenos.com.tr/Uploads/Article_1272/7-12.pdf
dc.identifier.urihttp://hdl.handle.net/11727/4332
dc.description.abstractObjective: In this study, we aimed to investigate the association of W64R polymorphism of the beta 3-adrenergic receptor gene (beta-3AR) with childhood obesity and related pathologies. Methods: beta-3AR gene W64R genotyping was carried out in 251 children aged 6-18 years. Of these subjects, 130 were obese (62 boys) and 121 were normal-weight (53 boys). In the obese group, fasting lipids, glucose and insulin levels were measured. Oral glucose tolerance test (OGTT) was performed in 75 of the obese patients. Results: The frequency of W64R genotype was similar in obese and nonobese children. In obese children, relative body mass index, waist-to-hip ratio, serum lipid, glucose and insulin levels, as well as homeostasis model assessment of insulin resistance (HOMA-IR) scores were not different between Arg allele carriers (W64R and R64R) and noncarriers (W64W). In 75 obese children, OGTT results showed that Arg allele carriers had significantly higher 30-minute glucose levels (p=0.027). Conclusion: W64R polymorphism of the beta-3AR gene is not associated with obesity and waist-to-hip ratio in Turkish children. Although there were no relationships between the genotypes and lipid, glucose/insulin levels or HOMA-IR, the presence of W64R variant seemed to have an unfavorable influence on early glucose excursion after glucose loading.en_US
dc.language.isoengen_US
dc.relation.isversionof10.4274/jcrpe.1629en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectObesityen_US
dc.subjectchildrenen_US
dc.subjectbeta 3-adrenergic receptor gene polymorphismen_US
dc.subjectoral glucose tolerance testen_US
dc.titlebeta-3AR W64R Polymorphism and 30-Minute Post-Challenge Plasma Glucose Levels in Obese Childrenen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGYen_US
dc.identifier.volume7en_US
dc.identifier.issue1en_US
dc.identifier.startpage7en_US
dc.identifier.endpage12en_US
dc.identifier.wos000351307200002


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