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dc.contributor.authorOnal, C.
dc.contributor.authorGuler, O.C.
dc.contributor.authorDolek, Y.
dc.date.accessioned2019-12-06T08:54:10Z
dc.date.available2019-12-06T08:54:10Z
dc.date.issued2015
dc.identifier.issn0007-1285
dc.identifier.urihttp://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4651195&blobtype=pdf
dc.identifier.urihttp://hdl.handle.net/11727/4336
dc.description.abstractObjective: To evaluate the incidence, size and predisposing factors for air pockets around the vaginal cylinder and their dosimetric effect on the vaginal mucosa. Methods: We investigated 174 patients with endometrial carcinoma treated with external radiotherapy (RT) and brachytherapy (BRT) (101 patients, 58%) or BRT alone (73 patients, 42%). The quantity, volume and dosimetric impact of the air pockets surrounding the vaginal cylinder were quantified. The proportions of patients with or without air pockets during application were stratified according to menopausal status, treatment modality and interval between surgery and RT. Results: Air pockets around the vaginal cylinder were seen in 75 patients (43%), while 99 patients (57%) had no air pockets. Only 11 patients (6.3%) received less than the prescribed dose (average 93.9% of prescribed dose; range, 79.0-99.2%). Air pockets were significantly fewer in pre-menopausal patients or in patients treated with the combination of external RT and BRT than in postmenopausal patients or patients treated with BRT alone. A significant correlation existed between the mucosal displacement of the air gap and the ratio of the measured dose at the surface of the air gap and prescribed dose (Pearson r = -0.775; p < 0.001). Conclusion: Air pockets were still a frequent problem during vaginal vault BRT, especially in post-menopausal patients or in patients treated with BRT alone, which may potentially cause dose reductions at the vaginal mucosa. Advances in knowledge: Air pockets around the vaginal cylinder remain a significant problem, which may potentially cause dose reduction in the target volume.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1259/bjr.20140694en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDOSE-RATE BRACHYTHERAPYen_US
dc.subjectENDOMETRIAL CANCERen_US
dc.subjectAMERICAN BRACHYTHERAPYen_US
dc.subjectRANDOMIZED-TRIALen_US
dc.subjectRADIOTHERAPYen_US
dc.subjectCARCINOMAen_US
dc.subjectAAPMen_US
dc.titleThe impact of air pockets around the vaginal cylinder on vaginal vault brachytherapyen_US
dc.typearticleen_US
dc.relation.journalBRITISH JOURNAL OF RADIOLOGYen_US
dc.identifier.volume88en_US
dc.identifier.issue1047en_US
dc.identifier.wos000350882800017en_US
dc.identifier.scopus2-s2.0-84923445360en_US
dc.contributor.pubmedID25562767en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US


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