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dc.contributor.authorYavuz Taslipinar, Mine
dc.contributor.authorKilic, Nedret
dc.contributor.authorBayraktar, Nilufer
dc.contributor.authorGuler, Ismail
dc.contributor.authorGulcan Kurt, Yasemin
dc.contributor.authorGoktas, Tayfun
dc.contributor.authorTaner, Mehmet Zeki
dc.contributor.authorHimmetoglu, Mehmet Ozdemir
dc.contributor.authorYaman, Halil
dc.contributor.authorTaslipinar, Abdullah
dc.date.accessioned2019-12-17T12:43:19Z
dc.date.available2019-12-17T12:43:19Z
dc.date.issued2014
dc.identifier.issn1300-0144
dc.identifier.urihttp://journals.tubitak.gov.tr/medical/issues/sag-14-44-5/sag-44-5-12-1401-4.pdf
dc.identifier.urihttp://hdl.handle.net/11727/4465
dc.description.abstractBackground/aim: To evaluate whether there is a correlation between insulin resistance and nitric oxide-related endothelial dysfunction in patients with polycystic ovarian syndrome (PCOS). Materials and methods: The study was conducted with 25 young women with PCOS and 25 young healthy women, between 18 and 35 years of age. Plasma asymmetric dimethylarginine (ADMA) levels, serum nitric oxide (NO) levels, and homeostatic model assessment of insulin resistance (HOMA-IR) rates were measured in both the patient and control groups. Results: Plasma ADMA levels were significantly higher in PCOS patients than in the controls (P = 0.001). Serum NO levels were significantly lower in patients than in the controls (P = 0.008). The HOMA-IR rates, accepted as an insulin resistance parameter, were significantly higher in patients than in the controls (P = 0.001). Conclusion: Results of the present study indicate that, independent of age, body mass index, and blood lipid profile, there is significant insulin resistance in PCOS patients. However, no correlation was found between HOMA-IR as an insulin resistance determinant and altered ADMA and NO levels. This finding may indicate that there are additional mechanisms of cardiovascular risks in PCOS patients other than insulin resistance.en_US
dc.language.isoengen_US
dc.relation.isversionof10.3906/sag-1401-4en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPolycystic ovarian syndromeen_US
dc.subjectendothelial dysfunctionen_US
dc.subjectinsulin resistanceen_US
dc.subjectasymmetric dimethylarginineen_US
dc.subjectnitric oxideen_US
dc.titleEndothelial dysfunction and insulin resistance in young women with polycystic ovarian syndromeen_US
dc.typearticleen_US
dc.relation.journalTURKISH JOURNAL OF MEDICAL SCIENCESen_US
dc.identifier.volume44en_US
dc.identifier.issue5en_US
dc.identifier.startpage787en_US
dc.identifier.endpage791en_US
dc.identifier.wos000343068800012en_US
dc.identifier.scopus2-s2.0-84905672618en_US
dc.contributor.pubmedID25539546en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US


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