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dc.contributor.authorHaberal, Mehmet
dc.contributor.authorKirnap, Mahir
dc.contributor.authorErdem, S.Remzi
dc.contributor.authorOzdemir, B.Handan
dc.contributor.authorLux, K. Michael
dc.contributor.authorBacanli, Didem
dc.date.accessioned2020-07-17T12:02:34Z
dc.date.available2020-07-17T12:02:34Z
dc.date.issued2019
dc.identifier.issn1304-0855en_US
dc.identifier.urihttp://hdl.handle.net/11727/4783
dc.description.abstractObjectives: Organ damage due to long cold ischemia time remains a hurdle in transplantation. In this preliminary animal study, we compared the new Baskent University Preservation Solution (BUPS) with the University of Wisconsin (UW) and histidine-tryptophan-ketoglutarate (HTK) solutions. Materials and Methods: BUPS composition included electrolytes, raffinose, mannitol, N-acetylcysteine, taurine, adenosine, and ascorbic acid. In experiment 1, kidneys from 50 male Sprague-Dawley rats were placed into BUPS, HTK, or UW solution to assess cold ischemia injury, with biopsies taken at different time points for pathologic evaluation. In experiment 2, to investigate ischemia-reperfusion injury, 5 rats were renal transplant donors to 10 rats and 6 pigs were used as transplant donors-recipients among each other. Results: In experiment 1, no significant cellular injury was shown at up to 3 hours of perfusion with any solution. At 6- to 48-hour perfusion, tubular injury was shown, with lowest injury in BUPS and HTK versus UW and control groups (P < .01). The BUPS group showed more moderate degree of tubular apoptosis and cytoskeletal rearrangement than the HTK and UW groups at 12-, 24-, and 48-hour perfusion (P < .01). In experiment 2, after ischemia-reperfusion injury, no significant differences were found between HTK and BUPS groups regarding tubular damage. Although no significant differences were shown regarding tubular cytoskeletal rearrangment and apoptosis in pig reperfusion group with BUPS versus HTK, significant differences were shown with these solutions in other groups. Conclusions: Tubular damage during ischemia-reperfusion injury (cytoskeletal disruption, increased apoptosis) were lower with BUPS. BUPS can be a costeffective perfusion solution in transplantation.en_US
dc.language.isoengen_US
dc.relation.isversionof10.6002/ect.bups2019en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCold ischemia timeen_US
dc.subjectOrgan preservation solutionen_US
dc.subjectPreliminary experimenten_US
dc.titleEvaluation of New Baskent University Preservation Solution for Kidney Graft During Cold Ischemia: Preliminary Experimental Animal Studyen_US
dc.typearticleen_US
dc.relation.journalEXPERIMENTAL AND CLINICAL TRANSPLANTATIONen_US
dc.identifier.volume17en_US
dc.identifier.issue3en_US
dc.identifier.startpage287en_US
dc.identifier.endpage297en_US
dc.identifier.wos000504883700001en_US
dc.identifier.scopus2-s2.0-85067286549en_US
dc.contributor.pubmedID31145052en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US


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