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dc.contributor.authorNoyan, Figen
dc.contributor.authorAytan, Pelin
dc.date.accessioned2020-10-13T10:51:24Z
dc.date.available2020-10-13T10:51:24Z
dc.date.issued2019
dc.identifier.issn1300-7777en_US
dc.identifier.urihttps://www.journalagent.com/tjh/pdfs/TJH_36_4_230_237.pdf
dc.identifier.urihttp://hdl.handle.net/11727/4872
dc.description.abstractObjective: The aim of the present study was to evaluate the efficacy and safety of eltrombopag, an oral thrombopoietin receptor agonist, in patients with chronic immune thrombocytopenia (ITP). Materials and Methods: A total of 285 chronic ITP patients (187 women, 65.6 %; 98 men, 34.4%) followed in 55 centers were enrolled in this retrospective cohort. Response to treatment was assessed according to platelet count (/mm(3)) and defined as complete (platelet count of >100,000/mm(3)), partial (30,000-100,000/mm(3) or doubling of platelet count after treatment), or unresponsive (<30,000/mm(3)). Clinical findings, descriptive features, response to treatment, and side effects were recorded. Correlations between descriptive, clinical, and hematological parameters were analyzed. Results: The median age at diagnosis was 43.9 +/- 20.6 (range: 3-95) years and the duration of follow-up was 18.0 +/- 6.4 (range: 6-28.2) months. Overall response rate was 86.7% (n=247). Complete and partial responses were observed in 182 (63.8%) and 65 (22.8%) patients, respectively. Thirty-eight patients (13.4%) did not respond to eltrombopag treatment. For patients above 60 years old (n=68), overall response rate was 89.7% (n=61), and for those above 80 years old (n=12), overall response rate was 83% (n=10). Considering thrombocyte count before treatment, eltrombopag significantly increased platelet count at the 1st, 2nd, 3rd, 4th, and 8th weeks of treatment. As the time required for partial or complete response increased, response to treatment was significantly reduced. The time to reach the maximum platelet levels after treatment was quite variable (1-202 weeks). Notably, the higher the maximum platelet count after eltrombopag treatment, the more likely that side effects would occur. The most common side effects were headache (21.6%), weakness (13.7%), hepatotoxicity (11.8%), and thrombosis (5.9%). Conclusion: Results of the current study imply that eltrombopag is an effective therapeutic option even in elderly patients with chronic ITP. However, patients must be closely monitored for response and side effects during treatment. Since both response and side effects may be variable throughout the follow-up period, patients should be evaluated dynamically, especially in terms of thrombotic risk factors.en_US
dc.language.isoengen_US
dc.relation.isversionof10.4274/tjh.galenos.2019.2018.0307en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThrombocytopeniaen_US
dc.subjectImmune thrombocytopenicen_US
dc.subjectEltrombopagen_US
dc.titleA Multi-Center Study on the Efficacy of Eltrombopag in Management of Refractory Chronic Immune Thrombocytopenia: A Real-Life Experienceen_US
dc.typearticleen_US
dc.relation.journalTURKISH JOURNAL OF HEMATOLOGYen_US
dc.identifier.volume36en_US
dc.identifier.issue4en_US
dc.identifier.startpage230en_US
dc.identifier.endpage237en_US
dc.identifier.wos000497303100003en_US
dc.identifier.scopus2-s2.0-85075099354en_US
dc.contributor.pubmedID31327186en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US


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