Are There Any Predictors of Endometrial Premalignancy/Malignancy within Endometrial Polyps in Infertile Patients?
Tarih
2019Yazar
Tohma, Yusuf Aytac
Onalan, Gogsen
Esin, Sertac
Sahin, Hanifi
Aysun, Dide
Kuscu, Esra
Haberal, Ali
Zeyneloglu, Hulusi Bulent
Üst veri
Tüm öğe kaydını gösterÖzet
Background: In the literature, there is no detailed analysis on the prediction factors for premalignancy/malignancy within endometrial polyps (EPs) in infertile patients. In this study, we aimed to determine the frequency of endometrial premalignancy/malignancy within EPs in infertile patients undergoing office hysteroscopic polypectomy and identify the factors that can potentially predict an endometrial premalignancy/malignancy within EPs. Method: A total of 957 infertile patients undergoing office hysteroscopy were diagnosed with EPs between February 2011 and August 2018. Patients were divided into 2 groups according to the pathological examination of EPs as benign (Group 1; n = 939) and premalignant/malignant (Group 2; n = 18). The medical records of all patients included in the study were reviewed retrospectively. Results: In this cohort, prevalence of endometrial premalignancy/malignancy within EPs was 18/957 (1.88%). On univariate analysis, age, polyp size, diabetes, hypertension, and causes of infertility did not differ between the 2 groups. On multivariate analysis, diffuse polypoid appearance of the endometrial cavity on office hysteroscopy (hazard ratio [HR] 4.1; 95% CI 1.576-10.785), duration of infertility, (HR 4; 95% CI 1.279-12.562), and body mass index (HR 7.9; 95% CI 2.591-24.258) were found to be independent predictors of endometrial premalignancy/malignancy within polyps in infertile patients. Conclusion: When diffuse polypoid appearance of the endometrial cavity is detected in an infertile patient during office hysteroscopy, hysteroscopy-guided resection and endometrial curettage should be performed. The pathological specimen should be sent for histopathological evaluation to diagnose possible endometrial premalignancy/malignancy within polyps.
Bağlantı
http://hdl.handle.net/11727/5029Koleksiyonlar
İlgili Öğeler
Başlık, yazar, küratör ve konuya göre gösterilen ilgili öğeler.
-
Analysis of Bcl-2, PTEN, p53, and Ki-67 expressions in endometrial cancer arising from endometrial polyp
Karakas, L. A.; Tohma, Y. A.; Kuscu, E.; Ozen, O.; Ayhan, A. (2019)Objective: To compare the expression of the proliferation marker Ki-67, the antiapoptotic protein Bcl-2, and the tumor suppressor genes p53 and PTEN between endometrial cancer arising from endometrial polyp and benign ... -
Could The Long-Term Oncological Safety of Laparoscopic Surgery in Low Risk Endometrial Cancer Be Also Valid For The High Intermediate And High-Risk Patients? A Multi-Center Turkish Gynecologic Oncology Group Study Conducted with 2745 Endometrial Cancer Cases
Vardar, M. A.; Guzel, A. B.; Taskin, S.; Gungor, M.; Ozgul, N.; Salman, C.; Gulec, U. Kucukgoz; Khatib, G.; Dunder, I.; Ortac, F.; Yuce, K.; Terek, C.; Simsek, T.; Ozsaran, A.; Taskiran, C.; Onan, A.; Coban, G.; Topuz, S.; Demirkiran, F.; Takmaz, O.; Kose, M. F.; Gocmen, A.; Seydaoglu, G.; Gumurdulu, D.; Ayhan, A. (2019) -
Analysis of Bcl-2, Pten, P53 and Ki-67 Expressions in Endometrial Cancer Arising from Endometrial Polyp: Preliminary Results
Atasoy, L.; Kuscu, U. E.; Akilli, H.; Haberal, A.; Ayhan, A. (2017)