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dc.contributor.authorAysan, Erhan
dc.contributor.authorAydin, Ozan
dc.contributor.authorErcivan, Merve
dc.contributor.authorAksoy, Direnc
dc.contributor.authorYavuz, Alp Erdem
dc.date.accessioned2020-12-21T13:34:21Z
dc.date.available2020-12-21T13:34:21Z
dc.date.issued2019
dc.identifier.issn0894-1939en_US
dc.identifier.urihttp://hdl.handle.net/11727/5122
dc.description.abstractBackground: Microcalcifications are the most important diagnostic parameter for thyroid cancer. We developed a new imaging technique based on low dose X-rays that specifically reveal microcalcifications via a new software algorithm. Method: A prospective clinical trial was planned and 45 cases (37 women, 8 men, women/men: 4.6, age range: 17-68, mean age: 43) were included in the study. After total thyroidectomy with standard technique, the fresh thyroid tissues were integrated into the human neck simulator. Raw (DICOM) images were obtained for each tissue sample with a standard mammography device and transformed into new images (thyroidograms) by a new software algorithm. Preoperative ultrasonography (USG) images, DICOM images, and thyroidograms were evaluated in order to observe micro and macrocalcifications by the same experienced radiologist. Results: Twenty-four cases were malignant and 21 cases were benign after histopathologic evaluation. Microcalcification detection with the thyroidography was statistically significant for sensitivity, positive predictive value, negative predictive value, and accuracy (p < 0.05) but not for specificity (p > 0.05) compared to the USG and DICOM images for the malignant and also benign cases. Conclusion: This new imaging technique is hopeful for diagnosis of thyroid cancer according to microcalcification detection and may complement thyroid USG.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1080/08941939.2019.1586016en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectthyroiden_US
dc.subjectdiagnosisen_US
dc.subjectendocrineen_US
dc.subjectcanceren_US
dc.subjectnewen_US
dc.subjecttechniqueen_US
dc.titleA New Imaging Technique for the Diagnosis of Thyroid Cancer: Thyroidographyen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF INVESTIGATIVE SURGERYen_US
dc.identifier.wos000480216200001en_US
dc.identifier.scopus2-s2.0-85063910971en_US
dc.contributor.pubmedID31387418en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US


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