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dc.contributor.authorNasseri, Behzad
dc.contributor.authorKocum, Ismail Cengiz
dc.contributor.authorSeymen, Cemile Merve
dc.contributor.authorRebiee, Navid
dc.date.accessioned2020-12-24T08:16:54Z
dc.date.available2020-12-24T08:16:54Z
dc.date.issued2019
dc.identifier.issn1751-8741en_US
dc.identifier.urihttp://hdl.handle.net/11727/5138
dc.description.abstractIn present study, the effective penetration of radiofrequency (RF) induced gold decorated iron oxide nanoparticles (GS@IONPs) hyperthermia was investigated. The effective penetration depth of RF also the damage potency of hyperthermia was evaluated during histopathology observations which were done on the chicken breast tissue and hepatocellular carcinoma (HCC) models. The thermal damages are well- documented in our previous cellular study which was engaged with potency of RF hyperthermia in Epithelial adenocarcinoma (MCF-7) and fibroblast (L-929) cells deaths [1]. In recent work, PEGylated iron oxide nanoparticles (IONPs) were used as base platform for gold magnetic nanoparticles (GS@IONPs) formation. The 144.00015 MHz, 180W RF generator was applied for stimulating the nanoparticles. The chicken breast tissue and the hepatocellular tumor model was considered in the experimental section. In histology studies, the structural changes also the effective penetration depth of RF induced nanoparticles was observed through microscopic monitoring of the tissue slices in histology observations (Gazi medical school). The highest damage level was seen in 8.0 mu m tissue slices where lower damages were seen in depth of 1.0 cm and more inside tissue. The histology observations clarified the effective penetration depth of RF waves and irreversible damages in the 2.0 cm inside the tissue.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1049/iet-nbt.2019.0066en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectnanomedicineen_US
dc.subjecttumoursen_US
dc.subjectbiomedical materialsen_US
dc.subjectcellular biophysicsen_US
dc.subjectnanoparticlesen_US
dc.subjectgolden_US
dc.subjectcanceren_US
dc.subjecthyperthermiaen_US
dc.subjectmagnetic particlesen_US
dc.subjectiron compoundsen_US
dc.subjectradiation therapyen_US
dc.subjectAu-Fe3O4en_US
dc.subjectdepth 1en_US
dc.subject0 cmen_US
dc.subjectdepth 8en_US
dc.subject0 mumen_US
dc.subjectpower 180en_US
dc.subject0 Wen_US
dc.subjectsize 2en_US
dc.subject0 cmen_US
dc.subjectfrequency 144en_US
dc.subject00015 MHzen_US
dc.subjectmicroscopic monitoringen_US
dc.subjectstructural changesen_US
dc.subjecthepatocellular tumour modelen_US
dc.subjectstanding wave ratioen_US
dc.subjectpropylene glycolen_US
dc.subjectthermal damagesen_US
dc.subjecthepatocellular carcinoma modelsen_US
dc.subjectradiofrequency hyperthermiaen_US
dc.subjectnanoparticle dispersionen_US
dc.subjecttissue alterationsen_US
dc.subjectmodified tissuesen_US
dc.subjectgold shell magnetic nanoparticlesen_US
dc.subjectchicken breast tissueen_US
dc.subjectgold-coated iron oxide nanoparticlesen_US
dc.subjectpathology observationsen_US
dc.subjecteffective penetration depthen_US
dc.subjecthistology observationsen_US
dc.subjecttissue slicesen_US
dc.titlePenetration Depth in Nanoparticles Incorporated Radiofrequency Hyperthermia into the Tissue: Comprehensive Study with Histology and Pathology Observationsen_US
dc.typearticleen_US
dc.relation.journalIET NANOBIOTECHNOLOGYen_US
dc.identifier.volume13en_US
dc.identifier.issue6en_US
dc.identifier.startpage634en_US
dc.identifier.endpage639en_US
dc.identifier.wos000478917600014en_US
dc.identifier.scopus2-s2.0-85070412178en_US
dc.contributor.pubmedID31432798en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US


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